PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Nitrilotriacetic acid; (Aminotriacetic acid) | 139-13-9 |
2.00
15.01
11.01
3.09
3.01
16.02
|
||||||||||
| Formula | Synonyms | |||||||||||
| C6H9NO6 | NITRILOTRIACETIC ACID, ACETIC ACID, NITRILOTRI-, ALPHA,ALPHA^,ALPHA''-TRIMETHYLAMINETRICARBOXYLIC ACID, AMINOTRIACETIC ACID, CHEL 300, CHELEST NT, COMPLEXON I, DISODIUM NITRILOTRIACETATE, HAMPSHIRE NTA ACID, KOMPLEXON I, N,N-BIS(CARBOXYMETHYL)GLYCINE, N,N-BIS(CARBOXYMETHYL)GLYSINE, NCI-C02766, NITRILO-2,2',2''-TRIACETIC ACID, NITRILOTRIACETIC ACID AND SALTS, NITRILOTRIS(METHYLENECARBOXYLIC ACID), NTA, TITRIPLEX I, TRIGLYCINE, TRIGLYCOLLAMIC ACID, TRILON A, TRISODIUM NITRILOTRIACETATE, VERSENE NTA ACID | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 191.16 | S | 25 |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 8.0 | 36 | 220 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 1.0 | 4.6 | 28 |
Technical Basis
A review of available sources identified acute toxicity data (LD50) for various species (mouse, rat) and routes (oral, intraperitoneal), and exposure limits (OEL-TWAs, OEL-STELs, MAK-STEL). Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. The most preferred species and route data, a rat oral LD50, was selected as the TEEL-3 basis. The TEEL-2 was derived according to Table 3.5. The MAK-STEL was selected as the TEEL-1.
• PAC-1 = TEEL-1 = MAK-STEL (8 mg/m3)
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Rat oral LD50 (1100 mg/kg)
This review generated PAC values inconsistent with Rev. 29A. The Rev. 29A and current TEEL-3 basis are both rat oral LD50 toxicity data; however, this review found and used a more conservative dose. The Rev. 29A and current TEEL-2 methodology remains consistent, with the difference in values due to the change of the TEEL-3. The Rev. 29A TEEL-1 was derived from the TEEL-2 (Table 3.5), while the current TEEL-1 is an exposure limit, MAK-STEL.
• PAC-1 = TEEL-1 = MAK-STEL (8 mg/m3)
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Rat oral LD50 (1100 mg/kg)
This review generated PAC values inconsistent with Rev. 29A. The Rev. 29A and current TEEL-3 basis are both rat oral LD50 toxicity data; however, this review found and used a more conservative dose. The Rev. 29A and current TEEL-2 methodology remains consistent, with the difference in values due to the change of the TEEL-3. The Rev. 29A TEEL-1 was derived from the TEEL-2 (Table 3.5), while the current TEEL-1 is an exposure limit, MAK-STEL.
References
Chemical information: https://pubchem.ncbi.nlm.nih.gov/compound/Nitrilotriacetic-acid.
MAK-STEL: https://ilv.ifa.dguv.de/limitvalues/43894
Rat oral LD50: Angewandte Chemie, International Edition in English., 14(94), 1975. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/Nitrilotriacetic-acid.