PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Nitroaniline, 2-; (o-Nitroaniline) | 88-74-4 | 1661 |
11.01
4.05
11.00
8.00
13.00
7.01
4.10
4.07
3.02
3.10
|
|||||||||
| Formula | Synonyms | |||||||||||
| C6H6N2O2 | O-NITROANILINE, 1-AMINO-2-NITROBENZENE, 1-NITRO-2-AMINOBENZENE, 2-AMINONITROBENZENE, 2-NITROANILINE, 2-NITROBENZENAMINE, 2-NITROPHENYLAMINE, ANILINE, O-NITRO-, AZOENE FAST ORANGE GR BASE, AZOENE FAST ORANGE GR SALT, AZOFIX ORANGE GR SALT, AZOGENE FAST ORANGE GR, AZOIC DIAZO COMPONENT 6, BRENTAMINE FAST ORANGE GR BASE, BRENTAMINE FAST ORANGE GR SALT, C.I. 37025, C.I. AZOIC DIAZO COMPONENT 6, DEVOL ORANGE B, DEVOL ORANGE SALT B, DIAZO FAST ORANGE GR, FAST ORANGE BASE GR, FAST ORANGE BASE JR, FAST ORANGE GR BASE, FAST ORANGE GR SALT, FAST ORANGE O BASE, FAST ORANGE O SALT, FAST ORANGE SALT GR, FAST ORANGE SALT JR, HILTONIL FAST ORANGE GR BASE, HILTOSAL FAST ORANGE GR SALT, HINDASOL ORANGE GR SALT, NATASOL FAST ORANGE GR SALT, O-AMINONITROBENZENE, O-NITRANILINE, O-NITROPHENYLAMINE, ONA, ORANGE BASE CIBA II, ORANGE BASE IRGA II, ORANGE GRS SALT, ORANGE SALT CIBA II, ORANGE SALT IRGA II, ORTHONITROANILINE, UN 1661 | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 138.13 | S | 72 | 284.5 | 0.00277 | 25 | 0.9015 |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 10 | 53 | 320 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 1.8 | 9.4 | 57 |
Technical Basis
A review of available sources identified acute toxicity data (LD50, LC50, LDLo) and exposure limits (OEL-TWAs, OEL-STELs). Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. Although a 4-hour rat LC50 toxicity study was identified, adverse effects were not observed at the highest dose applied in the study; therefore, a rat oral LD50 was selected as the TEEL-3 basis. The OEL-STEL (Poland) was selected as the TEEL-1. The TEEL-2 value was derived according to Table 3.5.
• PAC-1 = TEEL-1 = OEL-STEL (Poland, 10 mg/m3)
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Rat oral LD50 (1600 mg/kg)
This review generated PAC values inconsistent with Rev. 29A. The Rev. 29A TEEL-3 basis was also a rat oral LD50, however this review found and used a more conservative dose. In Rev. 29A the TEEL-1 was derived according to Table 3.5, while this review used an OEL-STEL exposure limit. The TEEL-2 methodology remains consistent, with the difference in values due to the change of the TEEL-3 basis.
• PAC-1 = TEEL-1 = OEL-STEL (Poland, 10 mg/m3)
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Rat oral LD50 (1600 mg/kg)
This review generated PAC values inconsistent with Rev. 29A. The Rev. 29A TEEL-3 basis was also a rat oral LD50, however this review found and used a more conservative dose. In Rev. 29A the TEEL-1 was derived according to Table 3.5, while this review used an OEL-STEL exposure limit. The TEEL-2 methodology remains consistent, with the difference in values due to the change of the TEEL-3 basis.
References
Chemical information: https://pubchem.ncbi.nlm.nih.gov/compound/2-Nitroaniline.
OEL-STEL: https://ilv.ifa.dguv.de/limitvalues/43918
Rat oral LD50: Voprosy Kommunal'noi Gigieny. Problems of Communal Hygiene., 6(89), 1966 Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/2-Nitroaniline.
Rat LC50: https://chem.echa.europa.eu/100.001.687/dossier-view/066382c0-3269-4861-a4e7-1781a4621f80/IUC5-17ae8938-e575-4f5f-88e1-7bc2ce329794_228989d3-10ab-489f-b5ef-8b70ac2eafcd