PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Nitrophenol, 2-; (o-Nitrophenol) | 88-75-5 | 1663 |
14.02
11.01
13.00
4.08
7.01
7.00
8.00
11.00
4.05
4.09
|
|||||||||
| Formula | Synonyms | |||||||||||
| C6H5NO3 | 2-NITROPHENOL, 2-HYDROXYNITROBENZENE, O-HYDROXYNITROBENZENE, O-NITROPHENOL, ONP, ORTHO-NITROPHENOL, PHENOL, O-NITRO- | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 139.12 | S | 45 | 214.5 | 1 | 49.3 | 1.495 |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 1.0 | 11 | 66 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.18 | 1.9 | 12 |
Technical Basis
A review of available sources identified multiple animal toxicity data. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route based on the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. A rat oral LD50 was the most preferred exposure and was selected as the basis to calculate the TEEL-3 value. The TEEL-2 and TEEL-1 were calculated from this TEEL-3 value, according to Table 3.5.
• TEEL-1 = TEEL-1/11
• TEEL-2 = TEEL-3/6
• TEEL-3= Rat oral LD50 (334 mg/kg)
This review generated TEEL values that are more conservative than Rev. 29A. The prior TEEL-3 was based on mouse oral LD50 (1,300 mg/kg), but the recommended TEEL-3 values are based higher priority, rat oral LD50 (334 mg/kg), and result in more conservative limits.
• TEEL-1 = TEEL-1/11
• TEEL-2 = TEEL-3/6
• TEEL-3= Rat oral LD50 (334 mg/kg)
This review generated TEEL values that are more conservative than Rev. 29A. The prior TEEL-3 was based on mouse oral LD50 (1,300 mg/kg), but the recommended TEEL-3 values are based higher priority, rat oral LD50 (334 mg/kg), and result in more conservative limits.
References
https://cameochemicals.noaa.gov/chemical/8902
Rat oral LD50: Lewis, R.J. Sr. (ed) Sax's Dangerous Properties of Industrial Materials. 11th Edition. Wiley-Interscience, Wiley & Sons, Inc. Hoboken, NJ. 2004., p. 2692 via PubChem: National Center for Biotechnology Information (2023). PubChem Compound Summary for CID 6947, 2-Nitrophenol. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/2-Nitrophenol
National Center for Biotechnology Information (2023). PubChem Compound Summary for CID 6947, 2-Nitrophenol. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/2-Nitrophenol