PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Antimycin A | 1397-94-0 |
11.00
7.00
5.00
|
||||||||||
| Formula | Synonyms | |||||||||||
| C28H40N2O9 | ANTIMYCIN A, ANTIPIRICULLIN, FINTROL, VIROSIN | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 548.7 | S | 0.00001 | 25 |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.031 | 0.34 | 2.1 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.0014 | 0.015 | 0.094 |
Technical Basis
A review of available sources identified the following exposures: LD50 (dog, rat) for intraperitoneal and oral routes. Toxicity data were evaluated and selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and factors in Tables 3.2, 3.3, and 3.4. Of the data found, the dog oral LD50 was both the most preferred and conservative toxicity exposure and was selected the TEEL-3 basis. TEEL-2 and TEEL-1 were calculated from this TEEL-3 value, according to Table 3.5.
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = Estimated from dog oral LD50 (5 mg/kg)
This review generated TEEL values that are more conservative and therefore inconsistent with those of Rev. 29A due to a different toxicity exposure basis. The current recommendation is a more preferred species (dog > rat).
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = Estimated from dog oral LD50 (5 mg/kg)
This review generated TEEL values that are more conservative and therefore inconsistent with those of Rev. 29A due to a different toxicity exposure basis. The current recommendation is a more preferred species (dog > rat).
References
https://cameochemicals.noaa.gov/chemical/4866
Dog oral LD50: Antimicrobial Agents and Chemotherapy (1961-70), 757,1966; via PubChem: National Center for Biotechnology Information (2023). PubChem Compound Summary for CID 14957, antimycin A1. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/antimycin-A1
Rat intraperitoneal LD50: Cancer Research, 13,49,1953; via PubChem: National Center for Biotechnology Information (2023). PubChem Compound Summary for CID 14957, antimycin A1. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/antimycin-A1
Rat oral LD50: Antimicrobial Agents and Chemotherapy (1961-70), 757,1966; via PubChem: National Center for Biotechnology Information (2023). PubChem Compound Summary for CID 14957, antimycin A1. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/antimycin-A1