PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Nitrophenol, 4-; (p-Nitrophenol); Includes 25154-55-6 (mixed isomers) | 100-02-7 | 1663 |
13.00
15.01
11.01
4.08
4.05
7.01
8.00
11.00
4.07
3.05
|
|||||||||
| Formula | Synonyms | |||||||||||
| C6H5NO3 | 4-NITROPHENOL, 1-HYDROXY-4-NITROBENZENE, 4-HYDROXY-1-NITROBENZENE, 4-HYDROXYNITROBENZENE, MONONITROPHENOL, NCI-C55992, NIPHEN, NITROPHENOLS, P-HYDROXYNITROBENZENE, P-NITRO-PHENOL, P-NITROPHENOL, PARA-NITROPHENOL, PHENOL, 4-NITRO, PHENOL, P-NITRO-, PNP, UN 1663 | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 139.11 | S | 113.6 | 72.6 | 1.479 @ 20°C |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.51 | 5.6 | 34 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.090 | 0.98 | 6.0 |
Technical Basis
A review of available sources identified the following: LDLo (dog,) and LD50 (mouse, rat) for intravenous and oral routes. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected based on the type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2. These were evaluated using factors in Tables 3.2, 3.3, and 3.4. The lowest rat oral LD50 was selected as the TEEL-3 basis. TEEL-2 and TEEL-1 values were derived according to Table 3.5.
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = Rat Oral LD50 (170 mg/kg)
This review generated TEEL values inconsistent with Rev. 29A, although the methodology between Rev. 29A and this review are the same. The Rev. 29A rat oral LD50 basis was not found during the current review; instead, an available rat oral LD50 was used, resulting in comparable, but lower, TEEL values.
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = Rat Oral LD50 (170 mg/kg)
This review generated TEEL values inconsistent with Rev. 29A, although the methodology between Rev. 29A and this review are the same. The Rev. 29A rat oral LD50 basis was not found during the current review; instead, an available rat oral LD50 was used, resulting in comparable, but lower, TEEL values.
References
Numerous acute animal toxicity. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/4-Nitrophenol
Rat oral LD50 (female). USEPA/Office of Pesticide Programs; Registration Eligibility Decision Document - Paranitrophenol, p.5, EPA 738-R-97-016 (January 1998), see Table 1. Retrieved from: https://archive.epa.gov/pesticides/reregistration/web/pdf/2465red.pdf