PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Nitrosodipropylamine; (DPNA) | 621-64-7 |
11.00
4.10
4.07
2.00
2.02
3.10
3.07
5.00
5.10
|
||||||||||
| Formula | Synonyms | |||||||||||
| C6H14N2O | N-NITROSODI-N-PROPYLAMINE, DI-N-PROPYLNITROSAMINE, DIPROPYL NITROSAMINE, DIPROPYLAMINE, N-NITROSO-, DIPROPYLNITROSAMINE, DPN, DPNA, N,N-DIPROPYLNITROSAMINE, N-NITROSO-N-DI-N-PROPYLAMINE, N-NITROSO-N-DIPROPYLAMINE, N-NITROSO-N-PROPYL-1-PROPANAMINE, N-NITROSODIPROPYLAMINE, NDPA, NITROUS DIPROPYLAMIDE | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 130.22 | 206 | .92 @ 20°C |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 1.4 | 16 | 95 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.26 | 3.0 | 18 |
Technical Basis
A review of limited sources identified a rat and mouse LD50 for oral and subcutaneous routes. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. The rat oral LD50 was selected as the TEEL-3 basis. TEEL-2 and TEEL-1 values were calculated according to Table 3.5.
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = Rat oral LD50 (480 mg/kg)
This review generated TEEL-3 values that are consistent with those in Rev. 29A. Currently recommended TEEL-2 and TEEL-1 values are more conservative than Rev. 29A because of their derivation from the TEEL-3; the TEEL-2 basis reported in Rev. 29A (a TDLo) was not found during current review.
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = Rat oral LD50 (480 mg/kg)
This review generated TEEL-3 values that are consistent with those in Rev. 29A. Currently recommended TEEL-2 and TEEL-1 values are more conservative than Rev. 29A because of their derivation from the TEEL-3; the TEEL-2 basis reported in Rev. 29A (a TDLo) was not found during current review.
References
https://pubchem.ncbi.nlm.nih.gov/compound/N-Nitrosodipropylamine
Rat oral LD50: Zeitschrift fuer Krebsforschung., 69(103), 1967 [PMID:4230610]. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/N-Nitrosodipropylamine.