PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Nitrotoluene, m- | 99-08-1 | 1664 |
13.00
4.05
7.01
15.01
4.08
7.00
11.00
4.10
4.07
3.05
|
|||||||||
| Formula | Synonyms | |||||||||||
| C7H7NO2 | M-NITROTOLUENE, 1-METHYL-3-NITROBENZENE, 3-METHYL NITROBENZENE, 3-METHYL-1-NITROBENZENE, 3-METHYLNITROBENZENE, 3-NITROTOLUENE, 3-NITROTOLUOL, M-METHYLNITROBENZENE, M-MONONITROTOLUENE, M-NITROPHENYLMETHANE, META-NITROTOLUENE, MNT, TOLUENE, M-NITRO- | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 137.15 | L | 16 | 231.9 | 0.27 | 25 | 1.1630 @ 15°C |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 2.0 | 14 | 200 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 11 | 79 | 1100 |
Technical Basis
A review of available sources identified acute toxicity data (LD50, TDLo) for various species and routes, and exposure limits (TWAs, OEL-STELs, IDLH). Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. The 1990 IDLH was selected as the TEEL-3. Multiple rat oral TDLo studies were evaluated; the lowest duration and dose TDLo was selected as the TEEL-2 basis (Section 3.3.1, 3.3.2). The lowest reported OEL-STEL (Sweden, 15-minute average value) was selected as the TEEL-1.
• PAC-1 = TEEL-1 = OEL-STEL (Sweden, 2 ppm, 11 mg/m3)
• PAC-2 = TEEL-2 = Rat oral TDLo (10000 mg/kg/4W, intermittent; toxicity endpoint: dyspnea)
• PAC-3 = TEEL-3 = IDLH (1990, o-, m-, p- nitrotoluene isomers; 200 ppm)
This review generated PAC-3 and PAC-2 values consistent with Rev. 29A, and an inconsistent PAC-1 value. The Rev. 29A and current TEEL-3 and TEEL-2 values, sources, and methodology remain consistent. The Rev. 29A TEEL-1 basis was the TLV-TWA, while the current TEEL-1 basis an OEL-STEL, a more preferred limit (Table 3.5, Note).
• PAC-1 = TEEL-1 = OEL-STEL (Sweden, 2 ppm, 11 mg/m3)
• PAC-2 = TEEL-2 = Rat oral TDLo (10000 mg/kg/4W, intermittent; toxicity endpoint: dyspnea)
• PAC-3 = TEEL-3 = IDLH (1990, o-, m-, p- nitrotoluene isomers; 200 ppm)
This review generated PAC-3 and PAC-2 values consistent with Rev. 29A, and an inconsistent PAC-1 value. The Rev. 29A and current TEEL-3 and TEEL-2 values, sources, and methodology remain consistent. The Rev. 29A TEEL-1 basis was the TLV-TWA, while the current TEEL-1 basis an OEL-STEL, a more preferred limit (Table 3.5, Note).
References
Chemical information: https://pubchem.ncbi.nlm.nih.gov/compound/3-Nitrotoluene.
OEL-STEL: https://ilv.ifa.dguv.de/limitvalues/45116
Rat oral TDLo (10000 mg/kg/4W). HPV285, 2001. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/7422#section=NIOSH-Toxicity-Data
IDLH: https://www.cdc.gov/niosh/idlh/88722.html