PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Acetyl carbinol; (Acetol (1); 1-Hydroxy-2-propanone) | 116-09-6 |
15.01
11.01
9.00
4.11
|
||||||||||
| Formula | Synonyms | |||||||||||
| C3.H6.O2 | ||||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 74.09 | L | -7 | 1.082 |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 6.0 | 66 | 400 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 2.0 | 22 | 130 |
Technical Basis
A review of available sources identified the following rat oral LD50 toxicity data. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. Of the toxicity data, the most recent rat oral LD50 (2018) was selected as the TEEL-3 basis. TEEL-2 and TEEL-1 values were derived according to Table 3.5.
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = rat oral LD50 (>2000 mg/kg)
This review generated TEEL values that are inconsistent with Rev. 29A values. The Rev. 29A TEEL-3 basis was also a rat oral LD50 (1948); the current basis is a more recently reported value (Section 3.3.1). The Rev. 29A and current TEEL-2 and TEEL-1 values were derived using the same methodology, with differences due to the change in TEEL-3.
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = rat oral LD50 (>2000 mg/kg)
This review generated TEEL values that are inconsistent with Rev. 29A values. The Rev. 29A TEEL-3 basis was also a rat oral LD50 (1948); the current basis is a more recently reported value (Section 3.3.1). The Rev. 29A and current TEEL-2 and TEEL-1 values were derived using the same methodology, with differences due to the change in TEEL-3.
References
Rat oral LD50 (>2000 mg/kg): https://echa.europa.eu/de/registration-dossier/-/registered-dossier/27189/7/3/2
Rat oral LD50 (2200 mg/kg). Journal of Industrial Hygiene and Toxicology., 30(63), 1948. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/Hydroxyacetone.