PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Phenacetin; (p-Acetophenetidide) | 62-44-2 |
13.00
4.08
4.05
7.01
8.00
11.00
4.09
4.10
2.01
2.02
|
||||||||||
| Formula | Synonyms | |||||||||||
| C10H13NO2 | PHENACETIN, 1-ACETAMIDO-4-ETHOXYBENZENE, 4^-ETHOXYACETANILIDE, 4'ETHOXYACETANILIDE, 4-(ACETYLAMINO)PHENETOLE, 4-ETHOXYACETANILIDE, ACET-P-PHENALIDE, ACET-P-PHENETIDIN, ACET-PARA-PHENALIDE, ACETAMIDE,N-(4-ETHOXYPHENYL)-, ACETANILIDE,4'-ETHOXY-, ACETO-4-PHENETIDINE, ACETO-PARA-PHENALIDE, ACETO-PARA-PHENETIDIDE, ACETOPHENETIDIN, ACETOPHENETIDINE, ACETOPHENETIN, ACETPHENETIDIN, ACETYLPHENETIDIN, BROMO SELTZER, CORICIDIN, DARVON COMPOUND, EMPIRIN COMPOUND, FENIDINA, FENINA, KALMIN, N-(4-ETHOXYPHENYL)ACETAMIDE, N-ACETYL-4-ETHOXYANILINE, N-ACETYL-P-ETHOXYANILINE, N-ACETYL-P-PHENETIDINE, N-ACETYL-PARA-PHENETIDINE, N-PARA-ETHOXYPHENYL-ACETAMIDE, P-ACETOPHENETIDE, P-ACETOPHENETIDIDE, P-ACETOPHENETIDINE, P-ACETPHENETIDIN, P-ETHOXYACETANILIDE, P-PHENETIDINE, N-ACETYL, PARA-ACETOPHENETIDE, PARA-ACETOPHENETIDIDE, PARA-ACETOPHENETIDINE, PARA-ACETPHENETIDIN, PARA-ETHOXY-ACETANILID, PARA-ETHOXYACETANILIDE, PARA-PHENACETIN, PARACETOPHENTIDIN, PERCODAN, PERTONAL, PHENACET, PHENACETINE, PHENACITIN, PHENAZETIN, PHENEDINA, PHENIDIN, PHENIN, PYRAPHEN, SINUTAB | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 179.22 | S | 134 | 25 |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 15 | 54 | 330 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 2.0 | 7.4 | 45 |
Technical Basis
A review of available sources identified several acute toxicity data (LD50, LC50, LDLo) and an exposure limit (OEL-TWA). Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. Although inhalation is the most preferred route, the acute inhalation data (mouse LC50) did not have a duration reported; therefore, this data was not selected for TEEL development (Section 3.3.1). As such, the next most preferred species and route data, a rat oral LD50, was selected as the TEEL-3 basis. The TEEL-2 value was derived according to Table 3.5. The OEL-TWA (Poland) was selected as the TEEL-1 basis.
• PAC-1 = TEEL-1 = OEL-TWA (Poland, 5 mg/m3) x 3
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Rat oral LD50 (1650 mg/kg)
This review generated PAC-1 and PAC-2 values inconsistent with Rev. 29A and a consistent PAC-3 value. The Rev. 29A and current TEEL-3 values, sources, and methodology remain consistent. The Rev. 29A TEEL-2 basis was a rat oral TDLo that was not identified during this review; instead, the current TEEL-2 was derived from the TEEL-3 (Table 3.5). The Rev. 29A TEEL-1 was derived from the TEEL-2 (Table 3.5) while the current TEEL-1 basis is an exposure limit (OEL-TWA).
• PAC-1 = TEEL-1 = OEL-TWA (Poland, 5 mg/m3) x 3
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Rat oral LD50 (1650 mg/kg)
This review generated PAC-1 and PAC-2 values inconsistent with Rev. 29A and a consistent PAC-3 value. The Rev. 29A and current TEEL-3 values, sources, and methodology remain consistent. The Rev. 29A TEEL-2 basis was a rat oral TDLo that was not identified during this review; instead, the current TEEL-2 was derived from the TEEL-3 (Table 3.5). The Rev. 29A TEEL-1 was derived from the TEEL-2 (Table 3.5) while the current TEEL-1 basis is an exposure limit (OEL-TWA).
References
Chemical information: https://pubchem.ncbi.nlm.nih.gov/compound/Phenacetin.
OEL-TWA: https://ilv.ifa.dguv.de/limitvalues/48952
Rat oral LD50: Toxicology and Applied Pharmacology., 1(240), 1959. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/Phenacetin