PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Acetyl chloride | 75-36-5 | 1717 |
18.00
14.01
14.02
11.01
4.01
4.02
7.00
7.01
|
|||||||||
| Formula | Synonyms | |||||||||||
| C2H3ClO | ACETYL CHLORIDE, ACETIC ACID, CHLORIDE, ACETIC CHLORIDE, CHLORURE D^ACÉTYLE (DOT FRENCH), CLORURO DE ACETILO (DOT SPANISH), ETHANOYL CHLORIDE | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 78.5 | L | -112.8 | 50.7 | 287 | 25 | 1.1051 @ 20°C | 50000 |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 5.0 | 30 | 180 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 1.6 | 9.3 | 56 |
Technical Basis
A review of available sources identified human and rat acute toxicity data (TCLo, LD50) and an OEL-TWA (Romania). Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. A rat oral LD50 was selected as the TEEL-3 basis. The human TCLo was considered as a TEEL-2 basis, however the record was incomplete (Section 3.3.1). Instead, the TEEL-2 value was derived according to Table 3.5. The OEL-TWA was selected as the TEEL-1 basis.
• TEEL-1 = OEL-STEL (15-min, Romania, 5 mg/m3)
• TEEL-2 = TEEL-3/6
• TEEL-3 = Rat Oral LD50 (910 mg/kg)
This review generated TEEL-3 and TEEL-2 values consistent with Rev. 29A. The Rev. 29A and current TEEL-1 are inconsistent. The Rev. 29A TEEL-1 was derived from the TEEL-2, while the current TEEL-1 basis is an OEL-TWA (Section 3.4.2).
• TEEL-1 = OEL-STEL (15-min, Romania, 5 mg/m3)
• TEEL-2 = TEEL-3/6
• TEEL-3 = Rat Oral LD50 (910 mg/kg)
This review generated TEEL-3 and TEEL-2 values consistent with Rev. 29A. The Rev. 29A and current TEEL-1 are inconsistent. The Rev. 29A TEEL-1 was derived from the TEEL-2, while the current TEEL-1 basis is an OEL-TWA (Section 3.4.2).
References
Chemical information: https://pubchem.ncbi.nlm.nih.gov/compound/Acetyl-chloride
Rat Oral LD50: Lewis, R.J. Sr. (ed) Sax's Dangerous Properties of Industrial Materials. 11th Edition. Wiley-Interscience, Wiley & Sons, Inc. Hoboken, NJ. 2004., p. 42. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Acetyl-chloride
OEL-STEL (Romania). https://ilv.ifa.dguv.de/limitvalues/707