Technical Basis
A review of available sources identified acute toxicity data (LD50) for various species (rat, mouse, rabbit) and routes (oral, dermal). Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. The most preferred species and route data, rat oral LD50, were evaluated for the TEEL-3 basis, and the most conservative dose was selected. The dose is reported in units mL/kg; therefore, the reported density (0.973 g/mL at 25°C) was used to convert the dose to mg/kg. TEEL-1 and TEEL-2 values were derived according to Table 3.5.
• PAC-1 = TEEL-1 = TEEL-2/11
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Rat oral LD50 (1.07 mL/kg converted to 1041.11 mg/kg with density = 0.973 g/mL)
This review generated PAC values inconsistent with Rev. 29A. The Rev. 29A and current TEEL-3 basis are both rat oral LD50; however, the current value is based on a more conservative dose. The Rev. 29A and current TEEL-2 and TEEL-1 methodology remains consistent, with differences in values due to the change of the TEEL-3 basis.
References
Chemical information: https://pubchem.ncbi.nlm.nih.gov/compound/2-Phenyl-2-propanol.
Density retrieved from: https://www.sigmaaldrich.com/US/en/product/aldrich/p30802?srsltid=AfmBOooXhuo-_pcydldbk0wvcp1ljhGfTiKF7ZkKvv_xJdN2soTIwEvk
Rat oral LD50: Clayton, G. D. and F. E. Clayton (eds.). Patty's Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John Wiley Sons, 1981-1982., p. 4687. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/2-Phenyl-2-propanol.