PAC Database - Detailed Chemical Data

Chemical Identity
Chemical CAS# UN# Health Code Numbers
Phenylpropanolamine hydrochloride; (Propadrine hydrochloride) 154-41-6
5.00
4.08
7.01
Formula Synonyms
C9.H13.N.O.Cl.H PHENYLPROPANOLAMINE HYDROCHLORIDE, (+-)(R*,S*)-ALPHA-(1-AMINOETHYL)BENZENEMETHANOL HYDROCHLORID, (+-)-2-AMINO-1-PHENYL-1-PROPANOL HYDROCHLORIDE, (+-)-ALPHA-(1-AMINOETHYL)BENZYL ALCOHOL HYDROCHLORIDE, (+-)-NOREPHEDRINE CHLORIDE, (+-)-NOREPHEDRINE HYDROCHLORIDE, (+-)-PHENYLPROPANOLAMINE HYDROCHLORIDE, (.+-.)-NOREPHEDRINE CHLORIDE, (.+-.)-NOREPHEDRINE HYDROCHLORIDE, (.+-.)-PHENYLPROPANOLAMINE HYDROCHLORIDE, ALPHA-(1-AMINOETHYL)BENZENEMETHANOL HYDROCHLORIDE, ALPHA-(1-AMINOETHYL)BENZYL ALCOHOL HYDROCHLORIDE, ALPHA-HYDROXY-BETA-AMINOPROPYLBENZENE HYDROCHLORIDE, BENZENEMETHANOL, ALPHA-(1-AMINOETHYL)-, HYDROCHLORIDE, (R*,S, BENZENEMETHANOL, ALPHA-(1-AMINOETHYL)-, HYDROCHLORIDE, (R*,S, DL-1-PHENYL-2-AMINO-1-PROPANOL MONOHYDROCHLORIDE, DL-NOREPHEDRINE HYDROCHLORIDE, DL-PHENYLPROPANOLAMINE HYDROCHLORIDE, IP 58064, MONYDRIN, MUCORAMA, MYDRIATINE, NOREPHEDRINE HYDROCHLORIDE, NOREPHEDRINE, HYDROCHLORIDE, (.+-.)-, OBESTAT, PROPADRINE HYDROCHLORIDE
Physical Properties
Mol Wt State MP (°C) BP (°C) VP (Hg) VP (°C) SG LEL (ppm)
187.69 S
PAC Values
PAC Values (Original Units: mg/m3)
PAC-1 PAC-2 PAC-3
4.5 49 300
Converted PAC Values (ppm)
PAC-1 PAC-2 PAC-3
0.59 6.4 39
Technical Basis
A review of available sources identified several acute toxicity data (LD50, TDLo, LDLo) for various species (human, rat, mouse, guinea pig, rabbit) and routes (oral, intraperitoneal, intravenous). Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. The most preferred species and route data, a rat oral LD50, was selected as the TEEL-3 basis. The human oral TDLo was evaluated as the TEEL-2 basis; however, it was not selected because the record was incomplete (no sex reported, Section 3.3.1). TEEL-1 and TEEL-2 values were derived according to Table 3.5.
• PAC-1 = TEEL-1 = TEEL-2/11
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Rat oral LD50 (1490 mg/kg)
This review generated PAC values consistent with Rev. 29A*.
References
Chemical information: https://pubchem.ncbi.nlm.nih.gov/compound/Phenylpropanolamine-Hydrochloride.
Rat oral LD50: Toxicology and Applied Pharmacology., 18(185), 1971 [PMID:5542824]. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/Phenylpropanolamine-Hydrochloride.
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PAC values marked with a subscript "A" correspond to 60-minute AEGL values.
PAC values marked with a subscript "E" correspond to ERPG values.
PAC values marked by * are >= 10% lower explosive limit (LEL) but < 50% LEL.
PAC values marked by ** are > 50% LEL but < 100% LEL.
PAC values marked by *** are >= LEL.