Technical Basis
A review of available sources identified rabbit and rat acute toxicity data (LD50). Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. The most preferred species and route toxicity data, a rat oral LD50, was selected as the TEEL-3 basis. This value is reported in units of µL/kg, therefore it was converted using density (0.996 g/mL at 25°C). TEEL-2 and TEEL-1 values were derived according to Table 3.5.
• PAC-1 = TEEL-1 = TEEL-2/11
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Rat oral LD50 (2830 µL/kg, converted to 2818.7 mg/kg using a density of 0.996 g/mL)
This review generated PAC values consistent with Rev. 29A.
References
Chemical information: https://pubchem.ncbi.nlm.nih.gov/compound/Phenyltriethoxysilane
Density: https://www.sigmaaldrich.com/US/en/product/aldrich/175609
Rat LD50. Toxicology and Applied Pharmacology., 28(313), 1974 [PMID:4854023]. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/Phenyltriethoxysilane