PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Phosphamidon; (Famfos) | 13171-21-6 | 3018 |
6.00
14.01
11.00
4.05
7.01
7.00
4.01
4.09
4.10
4.07
|
|||||||||
| Formula | Synonyms | |||||||||||
| C10H19ClNO5P | PHOSPHAMIDON, 1-CHLORO-DIETHYLCARBAMOYL-1-PROPEN-2-YL DIMETHYL PHOSPHATE, 2-(N,N-DIETHYLCARBAMOYL)-1-METHYLVINYL PHOSPHATE, 2-CHLORO-2- DIETHYLCARBAMOYL-1-METHYLVINYL DIMETHYL PHOSPHAT, 2-CHLORO-2-DIETHYL CARBAMYL-1-METHYL VINYL DIMETHYL-PHOSPHAT, 2-CHLORO-2-DIETHYLCARBAMOYL-1-METHYLVINYL DIMETHYLPHOSPHATE, 2-CHLORO-2-DIETHYLCARBAMYL- 1-METHYLVINYL DIMETHYL PHOSPHATE, 2-CHLORO-3-(DIETHYLAMINO)-1-METHYL-3-OXO-1- PROPENYL DIMETHY, 2-CHLORO-N,N-DIETHYL-3-HYDROXYCROTONAMIDE DIMETHYL PHOSPHATE, C 570, CROTONAMIDE, 2-CHLORO-N,N-DIETHYL-3-HYDROXY-, DIMETHYL PHOSP, DIMECRON, DIMECRON 100, DIMECRON 20, DIMECRON 50, DIMECRON-20, DIMERCRON, DIMETHYL 2-CHLORO-3-(DIETHYLAMINO)-1-METHYL-3-OXO-1-PROPENYL, DIMETHYL DIETHYLAMIDO-1-CHLOROCROTONYL (2) PHOSPHATE, DIMETHYL PHOSPHATE OF 2-CHLORO-N,N-DIETHYL-3-HYDROXYCROTONAM, DIMETHYL-2-CHLORO-2-DIETHYLCARBAMOYL-1-METHYLVINYL PHOSPHATE, DIXON, ENT 25515, FAMFOS, MERKON, ML 97, N,N-DIETHYL 2-CHLORO-3-DIMETHYLPHOSPHATE CROTONAMIDE, NCI-C0058, NCI-C00588, O,O-DIMETHYL-O-(2-CHLORO-2-(N,N-DIETHYLCARBAMOYL)-1-METHYLVI, OR 1191, PHOSPHAMIDONE, PHOSPHORIC ACID, 2-CHLORO-3-(DIETHYLAMINO)-1-METHYL-3-OXO-1-, PHOSPHORIC ACID, DIMETHYL ESTER, ESTER WITH 2-CHLORO-N,N- DI, PHOSPHORIC ACID, DIMETHYL ESTER, ESTER WITH 2-CHLORO-N,N-DIE, SUNDARAM 1975 | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 299.72 | L | -45 | 350 | 0.000025 | 25 | 1.21 |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.027 | 0.30 | 6.0 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.0022 | 0.024 | 0.49 |
Technical Basis
A review of available sources identified several acute toxicity data (LD50, LC50) for various routes and species, and LOC. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. Inhalation exposures were scaled to 60-minute equivalents using the ten Berge equation (Section 3.3.4). Two LC50 toxicity studies (rat LC50 (135 mg/m3/4H) and mouse LC50 (30 mg/m3/1H) were evaluated for the TEEL-3 basis and resulted in similar values that were more conservative than Rev. 29A. The LC50 of the most preferred species, the 4-hour rat LC50, was selected as the TEEL-3 basis. The LOC was selected as the TEEL-2. The TEEL-1 value was derived according to Table 3.5.
• PAC-1 = TEEL-1 = TEEL-2/11
• PAC-2 = TEEL-2 = LOC (0.0003 gm/m3)
• PAC-3 = TEEL-3 = Rat LC50 (135 mg/m3/4H)
This review generated PAC-1 and PAC-2 values consistent with Rev. 29A and a PAC-3 value inconsistent with Rev. 29A. The Rev. 29A TEEL-3 basis was a dog oral LD50 that could not be found in the current review; instead, the highest priority source, a 4-hour rat LC50, was selected as the TEEL-3 basis. The TEEL-2 and TEEL-1 values, source, and methodology are consistent.
• PAC-1 = TEEL-1 = TEEL-2/11
• PAC-2 = TEEL-2 = LOC (0.0003 gm/m3)
• PAC-3 = TEEL-3 = Rat LC50 (135 mg/m3/4H)
This review generated PAC-1 and PAC-2 values consistent with Rev. 29A and a PAC-3 value inconsistent with Rev. 29A. The Rev. 29A TEEL-3 basis was a dog oral LD50 that could not be found in the current review; instead, the highest priority source, a 4-hour rat LC50, was selected as the TEEL-3 basis. The TEEL-2 and TEEL-1 values, source, and methodology are consistent.
References
Chemical information: https://pubchem.ncbi.nlm.nih.gov/compound/3032604
Rat LC50: Egeszsegtudomany., 24(173), 1980. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/3032604
LOC: Appendix C (page C-7) https://www.epa.gov/sites/default/files/2015-09/documents/technical_guidance_for_hazard_analysis.pdf