PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Physostigmine | 57-47-6 |
6.00
8.00
7.01
4.05
4.08
4.01
7.00
11.00
4.06
4.07
|
||||||||||
| Formula | Synonyms | |||||||||||
| C15H21N3 | PHYSOSTIGMINE, (-)-ESERINE, (-)-PHYSOSTIGMINE, CALABARINE, CARBAMIC ACID, METHYL-, ESTER WITH ESEROLINE, ERSERINE, ESERINE, ESEROLEIN, METHYLCARBAMATE(ESTER), ESROMIOTIN, EZERIN, MCV 4484, NIH 10421, PHYSOSTOL, PYRROLO(2,3-B)INDOL-5-OL, 1,2,3,3A,8,8A-HEXAHYDRO-1,3A,8-TRI, PYRROLO[2,3-B]INDOL-5-OL, 1,2,3,3A,8,8A-HEXAHYDRO-1,3A,8-TRI | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 275.39 | S | 0.00001 | 25 |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.41 | 4.5 | 27 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.036 | 0.40 | 2.4 |
Technical Basis
A review of available sources identified a LOC and acute toxicity data (LD50) for several routes and species. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were evaluated using factors in Tables 3.2, 3.3, and 3.4. The LOC was selected as the TEEL-2. Acute toxicity was considered for TEEL-3 development; however, the analysts prioritized the exposure limit (Section 3.1). TEEL-3 and TEEL-1 values were derived according to Table 3.5.
• PAC-1 = TEEL-1 = TEEL-2/11
• PAC-2 = TEEL-2 = LOC (0.0045 g/m3)
• PAC-3 = TEEL-3 = TEEL-2 x 6
This review generated PAC values consistent with Rev. 29A*.
• PAC-1 = TEEL-1 = TEEL-2/11
• PAC-2 = TEEL-2 = LOC (0.0045 g/m3)
• PAC-3 = TEEL-3 = TEEL-2 x 6
This review generated PAC values consistent with Rev. 29A*.
References
Chemical information: https://pubchem.ncbi.nlm.nih.gov/compound/5983
LOC. Appendix C, pg. C-8: https://www.epa.gov/sites/default/files/2015-09/documents/technical_guidance_for_hazard_analysis.pdf