PAC Database - Detailed Chemical Data

Chemical Identity
Chemical CAS# UN# Health Code Numbers
Physostigmine salicylate (1:1) 57-64-7
6.00
7.01
7.00
4.08
4.05
11.00
4.07
5.00
Formula Synonyms
C15H21N3O2.C7H6O3 PHYSOSTIGMINE, [SALICYLATE (1:1)], (-)-PHYSOSTIGMINE SALICYLATE, BENZOIC ACID, 2-HYDROXY-, COMPOUND WITH (3AS-CIS)-1,2,3,3A,8, BENZOIC ACID, 2-HYDROXY-, COMPOUND WITH(3AS-CIS)-1,2,3,3A,8,, ESERINE SALICYLATE, PHYSOSTIGMINE SALICYLATE, PHYSOSTIGMINE, MONOSALICYLATE, PHYSOSTIGMINE, SALICYLATE (1:1), PHYSOSTOL SALICYLATE, PYRROLO[2,3-B]INDOL-5-OL, 1,2,3,3A,8,8A-HEXAHYDRO-1,3A,8-TRI, PYRROLO[2,3-B]INDOL-5-OL, 1,2,3,3A,8,8A-HEXAHYDRO-1,3A,8-TRI, SALICYLIC ACID, COMPOUND WITH PHYSOSTIGMINE, SALICYLIC ACID, COMPOUND WITH PHYSOSTIGMINE (1:1)
Physical Properties
Mol Wt State MP (°C) BP (°C) VP (Hg) VP (°C) SG LEL (ppm)
413.52 S 0.00001 25
PAC Values
PAC Values (Original Units: mg/m3)
PAC-1 PAC-2 PAC-3
0.23 2.5 15
Converted PAC Values (ppm)
PAC-1 PAC-2 PAC-3
0.014 0.15 0.89
Technical Basis
A review of available sources identified a LOC and acute toxicity data (LD50, TDLo) for several routes and species. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were evaluated using factors in Tables 3.2, 3.3, and 3.4. The LOC was selected as the TEEL-2. Acute toxicity was considered for TEEL-3 development; however, the analysts prioritized the exposure limit (Section 3.1). TEEL-3 and TEEL-1 values were derived according to Table 3.5.
• PAC-1 = TEEL-1 = TEEL-2/11
• PAC-2 = TEEL-2 = LOC (0.0025 g/m3)
• PAC-3 = TEEL-3 = TEEL-2 x 6
This review generated PAC values consistent with Rev. 29A*.
References
Chemical information: https://pubchem.ncbi.nlm.nih.gov/compound/657348
LOC. Appendix C, pg. C-8. https://www.epa.gov/sites/default/files/2015-09/documents/technical_guidance_for_hazard_analysis.pdf
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PAC values marked with a subscript "A" correspond to 60-minute AEGL values.
PAC values marked with a subscript "E" correspond to ERPG values.
PAC values marked by * are >= 10% lower explosive limit (LEL) but < 50% LEL.
PAC values marked by ** are > 50% LEL but < 100% LEL.
PAC values marked by *** are >= LEL.