PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Polychlorinated biphenyl (Aroclor 1016); (Chlorodiphenyl (41% Cl)) | 12674-11-2 | 2315 |
14.01
4.01
11.01
15.02
4.05
7.00
11.00
2.00
3.05
7.11
|
|||||||||
| Formula | Synonyms | |||||||||||
| [Unspecified] | PCB-1016, AROCHLOR 1016, AROCLOR 1016, PCB 1016, POLYCHLORINATED BIPHENYL 1016 | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 0 | L | 1.44 @ 30°C |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 3.0 | 140 | 840 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0 | 0 | 0 |
Technical Basis
Analysts concurrently evaluated TEELs for the polychlorinated biphenyls (PCBs) Aroclor 1016 (41% chlorine, CASRN: 12674-11-2), Aroclor 1242 (42% chlorine, CASRN: 53469-21-9), and a mixture of Aroclor 1016 and Aroclor 1042 (reported as 37% chlorine in the PAC/TEEL database, no CASRN) for consistency between these similar chemicals. A review of available sources identified a rat oral LD50 for Aroclor 1016 (2300 mg/kg) and exposure limits (IDLH, TWAs) and acute toxicity (LD50, LDLo) for several species and routes for Aroclor 1242. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. Analysts determined that the use of the IDLH, which reports a combined value for PCBs with 42% and 54% chlorine, is not advised considering that 54% PCBs are uniquely toxic among PCB congeners. Instead, analysts evaluated available rat oral LD50 toxicity data. Of the available sources, analysts selected the rat oral LD50 that was published in peer reviewed journal (Aroclor 1242, CASRN: 53469-21-9; 4250 mg/kg) as the TEEL-3 basis (Sections 3.3.1 and 3.4.6). The TEEL-2 was derived according to Table 3.5. The TLV-TWA for chlorodiphenyl – 42% chlorine (CASRN: 53469-21-9) was selected as the TEEL-1 basis (Section 3.4.6).
• PAC-1 = TEEL-1 = TLV-TWA (chlorodiphenyl – 42% chlorine, CASRN: 53469-21-9; 1 mg/m3) x 3
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Rat oral LD50 (Aroclor 1242, CASRN: 53469-21-9, 4250 mg/kg)
This review generated PAC values inconsistent with Rev. 29A. The Rev. 29A TEEL-3 rat oral LD50 (2300 mg/kg) that was evaluated during this review; instead, the current TEEL-3 is rat oral LD50 for a similar chemical (Aroclor 1242, CASRN: 53469-21-9), from a more reliable source (Sections 3.3.1 and 3.4.6) which also considers similarities in Aloclor 1016 and Alochlor 1242 chlorination percentages. The Rev. 29A TEEL-2 basis was a mouse TDLo not found during the current review; instead, the TEEL-2 from the TEEL-3 (Table 3.5). The Rev. 29A TEEL-1 was derived from the TEEL-2, while the current TEEL-1 basis is a TLV-TWA for a similar chemical, a PCB mixture with approximately 42% chlorine, comparable to the 41% chlorine mixture of Aroclor 1016 (Section 3.4.6).
• PAC-1 = TEEL-1 = TLV-TWA (chlorodiphenyl – 42% chlorine, CASRN: 53469-21-9; 1 mg/m3) x 3
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Rat oral LD50 (Aroclor 1242, CASRN: 53469-21-9, 4250 mg/kg)
This review generated PAC values inconsistent with Rev. 29A. The Rev. 29A TEEL-3 rat oral LD50 (2300 mg/kg) that was evaluated during this review; instead, the current TEEL-3 is rat oral LD50 for a similar chemical (Aroclor 1242, CASRN: 53469-21-9), from a more reliable source (Sections 3.3.1 and 3.4.6) which also considers similarities in Aloclor 1016 and Alochlor 1242 chlorination percentages. The Rev. 29A TEEL-2 basis was a mouse TDLo not found during the current review; instead, the TEEL-2 from the TEEL-3 (Table 3.5). The Rev. 29A TEEL-1 was derived from the TEEL-2, while the current TEEL-1 basis is a TLV-TWA for a similar chemical, a PCB mixture with approximately 42% chlorine, comparable to the 41% chlorine mixture of Aroclor 1016 (Section 3.4.6).
References
Chemical information, see Table 4-3 and 4-4, retrieved from: https://www.atsdr.cdc.gov/toxprofiles/tp17-c4.pdf
FDA Status Report on the Chemistry and Toxicology of Polychlorinated Biphenyls (PCB) or Aroclors as of June 1, 1970. See Table 3. Retrieved from: https://cdn.toxicdocs.org/gw/gwZ1mO5gOwrZeYo20Rw0jK6a/gwZ1mO5gOwrZeYo20Rw0jK6a.pdf. These results are also reported in reference #3.
See Table 1. Fishbein, L. Annual Review of Pharmacology and Toxicology, Vol. 14, 1974, 139-159. Retrieved from: https://doi.org/10.1146/annurev.pa.14.040174.001035
R. Kimbrough, et al. Environmental Health Perspectives, 24, 1978. https://doi.org/10.1289/ehp.7824173
Rat oral LD50 for Aroclor 1016 (2300 mg/kg). National Technical Information Service., PB85-143766. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/38037
Rat oral LD50 for Aroclor 1242 (4250 mg/kg). Bruckner JV, Khanna KL, Cornish HH [1973]. Biological responses of the rat to polychlorinated biphenyls. Toxicol Appl Pharmacol 24:434-448. Retrieved from: https://www.cdc.gov/niosh/idlh/53469219.html
Guinea pig LDLo for Aloclor (345 mg/kg); see page Reference #11 (pg. 124 of PDF): EPA, Technical Directive Document No.02-8511-01, 1986. Retrieved from: https://extapps.dec.ny.gov/data/DecDocs/932104/Report.HW.932104.1986-04-15.NUSSiteInspection.pdf
IDLH for chlorodiphenyls (42% chlorine and 54% chlorine, CASRN: 53469-21-9 and 11109-69-1 respectively). Retrieved from: https://www.cdc.gov/niosh/idlh/53469219.html
OSHA TWAs for Aroclor 1242 (chlorodiphenyl – 42% chlorine, CASRN: 53469-2): https://www.osha.gov/chemicaldata/392
TLV-TWA for Aroclor 1242 (chlorodiphenyl – 42% chlorine, CASRN: 53469-2): https://www.acgih.org/chlorodiphenyl-42-chlorine/