PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Polychlorinated biphenyl (Aroclor 1016/1242): (Chlorodiphenyl (37% Cl)) | z-0042 | 2315 |
15.01
11.00
15.02
4.05
4.10
4.01
4.09
4.06
4.07
4.03
|
|||||||||
| Formula | Synonyms | |||||||||||
| [Unspecified] | ||||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 0 | L | 1.44 @ 30°C |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 3.0 | 140 | 840 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0 | 0 | 0 |
Technical Basis
Analysts concurrently evaluated TEELs for the polychlorinated biphenyls (PCBs) Aroclor 1016 (41% chlorine, CASRN: 12674-11-2), Aroclor 1242 (42% chlorine, CASRN: 53469-21-9), and a mixture of Aroclor 1016 and Aroclor 1042 (reported as 37% chlorine in the PAC/TEEL database, no CASRN) for consistency between these similar chemicals. A review of available sources identified a rat oral LD50 for Aroclor 1016 (2300 mg/kg) and exposure limits (IDLH, TWAs) and acute toxicity (LD50, LDLo) for several species and routes for Aroclor 1242. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. Analysts determined that the use of the IDLH, which reports a combined value for PCBs with 42% and 54% chlorine, is not advised considering that 54% PCBs are uniquely toxic among PCB congeners. Instead, analysts evaluated available rat oral LD50 toxicity data. Of the available sources, analysts selected the rat oral LD50 that was published in peer reviewed journal (CASRN: 53469-21-9, 4250 mg/kg) as the TEEL-3 basis (Sections 3.3.1 and 3.4.6). The TEEL-2 was derived according to Table 3.5. The TLV-TWA for chlorodiphenyl – 42% chlorine (CASRN: 53469-21-9) was selected as the TEEL-1 basis (Section 3.4.6).
• PAC-1 = TEEL-1 = TLV-TWA (chlorodiphenyl – 42% chlorine, CASRN: 53469-21-9; 1 mg/m3) x 3
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Rat oral LD50 (Aroclor 1242, CASRN: 53469-21-9, 4250 mg/kg)
This review generated PAC-3 and PAC-1 values inconsistent with Rev. 29A, and a consistent PAC-2 value. The Rev. 29A and current TEEL-3 basis are rat oral LD50; it‘s unclear if the Rev. 29A source was a different dose or minor differences in the values are due to rounding. The Rev. 29A and current TEEL-2 source, and methodology are consistent. The Rev. 29A TEEL-1 was derived from the TEEL-2, while the current TEEL-1 basis is a TLV-TWA for a similar chemical, a PCB mixture with approximately 42% chlorine, a component of this mixture.
• PAC-1 = TEEL-1 = TLV-TWA (chlorodiphenyl – 42% chlorine, CASRN: 53469-21-9; 1 mg/m3) x 3
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Rat oral LD50 (Aroclor 1242, CASRN: 53469-21-9, 4250 mg/kg)
This review generated PAC-3 and PAC-1 values inconsistent with Rev. 29A, and a consistent PAC-2 value. The Rev. 29A and current TEEL-3 basis are rat oral LD50; it‘s unclear if the Rev. 29A source was a different dose or minor differences in the values are due to rounding. The Rev. 29A and current TEEL-2 source, and methodology are consistent. The Rev. 29A TEEL-1 was derived from the TEEL-2, while the current TEEL-1 basis is a TLV-TWA for a similar chemical, a PCB mixture with approximately 42% chlorine, a component of this mixture.
References
Chemical information on Aloclor 1016 and 1242, see Table 4-3 and 4-4, retrieved from: https://www.atsdr.cdc.gov/toxprofiles/tp17-c4.pdf
FDA Status Report on the Chemistry and Toxicology of Polychlorinated Biphenyls (PCB) or Aroclors as of June 1, 1970. See Table 3. Retrieved from: https://cdn.toxicdocs.org/gw/gwZ1mO5gOwrZeYo20Rw0jK6a/gwZ1mO5gOwrZeYo20Rw0jK6a.pdf. These results are also reported in reference #3.
See Table 1. Fishbein, L. Annual Review of Pharmacology and Toxicology, Vol. 14, 1974, 139-159. Retrieved from: https://doi.org/10.1146/annurev.pa.14.040174.001035
R. Kimbrough, et al. Environmental Health Perspectives, 24, 1978. https://doi.org/10.1289/ehp.7824173
Rat oral LD50 for Aroclor 1016 (2300 mg/kg). National Technical Information Service., PB85-143766. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/38037
Rat oral LD50 for Aroclor 1242 (4250 mg/kg). Bruckner JV, Khanna KL, Cornish HH [1973]. Biological responses of the rat to polychlorinated biphenyls. Toxicol Appl Pharmacol 24:434-448. Retrieved from: https://www.cdc.gov/niosh/idlh/53469219.html
Guinea pig LDLo for Aloclor (345 mg/kg); see page Reference #11 (pg. 124 of PDF): EPA, Technical Directive Document No.02-8511-01, 1986. Retrieved from: https://extapps.dec.ny.gov/data/DecDocs/932104/Report.HW.932104.1986-04-15.NUSSiteInspection.pdf
IDLH for chlorodiphenyls (42% chlorine and 54% chlorine, CASRN: 53469-21-9 and 11109-69-1 respectively). Retrieved from: https://www.cdc.gov/niosh/idlh/53469219.html
OSHA TWAs for Aroclor 1242 (chlorodiphenyl – 42% chlorine, CASRN: 53469-2): https://www.osha.gov/chemicaldata/392
TLV-TWA for Aroclor 1242 (chlorodiphenyl – 42% chlorine, CASRN: 53469-2): https://www.acgih.org/chlorodiphenyl-42-chlorine/