PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Polychlorinated biphenyl (Aroclor 1221); (Chlorodiphenyl (21% Cl)) | 11104-28-2 | 2315 |
15.01
15.02
11.01
4.10
7.11
3.02
3.06
3.05
3.07
5.00
|
|||||||||
| Formula | Synonyms | |||||||||||
| 21% Cl | PCB-1221, AROCHLOR 1221, AROCLOR 1221, CHLORODIPHENYL (21 PERCENT CL), PCB 1221, POLYCHLORINATED BIPHENYL 1221 | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 192 | L | 1 | 0.0067 | 25 | 1.187 @ 15.5°C |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 3.0 | 130 | 790 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.38 | 17 | 100 |
Technical Basis
A review of available sources identified rat acute toxicity data (LD50) for oral and intraperitoneal routes. In addition, analysts evaluated exposure limits for the structurally similar chemical chlorodiphenyl - 42% chlorine (CASRN: 53469-21-9), with comparable toxicity, for TEEL development. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. Analysts determined that the use of the IDLH, which reports a combined value for polychlorinated biphenyls (PCBs) with 42% and 54% chlorine, is not advised considering that 54% PCBs are uniquely toxic among PCB congeners. Of the available rat oral LD50, analysts selected the dose that could be verified as the TEEL-3 basis (3980 mg/kg, Section 3.3.1). The TEEL-2 value was derived according to Table 3.5. The TLV-TWA for chlorodiphenyl – 42% chlorine (CASRN: 53469-21-9) was selected as the TEEL-1 basis (Section 3.4.6).
• PAC-1 = TEEL-1 = TLV-TWA (chlorodiphenyl – 42% chlorine, CASRN: 53469-21-9; 1 mg/m3) x 3
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Rat oral LD50 (3980 mg/kg)
This review generated PAC-3 and PAC-2 values consistent with Rev. 29A and an inconsistent PAC-1 value. The Rev. 29A and current TEEL-3 and TEEL-2 source, and methodologies are consistent. The Rev. 29A TEEL-1 was derived from the TEEL-2, while the current TEEL-1 basis is a TLV-TWA for a similar chemical (chlorodiphenyl – 42% chlorine, CASRN: 53469-21-9, Section 3.4.6).
• PAC-1 = TEEL-1 = TLV-TWA (chlorodiphenyl – 42% chlorine, CASRN: 53469-21-9; 1 mg/m3) x 3
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Rat oral LD50 (3980 mg/kg)
This review generated PAC-3 and PAC-2 values consistent with Rev. 29A and an inconsistent PAC-1 value. The Rev. 29A and current TEEL-3 and TEEL-2 source, and methodologies are consistent. The Rev. 29A TEEL-1 was derived from the TEEL-2, while the current TEEL-1 basis is a TLV-TWA for a similar chemical (chlorodiphenyl – 42% chlorine, CASRN: 53469-21-9, Section 3.4.6).
References
Chemical information, see Table 4-3 and 4-4. Retrieved from: https://www.atsdr.cdc.gov/toxprofiles/tp17-c4.pdf
Rat LD50. Lewis RJ (1996). Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/16322#section=Toxicity-Data&fullscreen=true
IDLH for chlorodiphenyls (42% chlorine and 54% chlorine, CASRN: 53469-21-9 and 11109-69-1 respectively). Retrieved from: https://www.cdc.gov/niosh/idlh/53469219.html
OSHA TWAs for Aroclor 1242 (chlorodiphenyl – 42% chlorine, CASRN: 53469-2): https://www.osha.gov/chemicaldata/392
TLV-TWA for Aroclor 1242 (chlorodiphenyl – 42% chlorine, CASRN: 53469-2): https://www.acgih.org/chlorodiphenyl-42-chlorine/