PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Polychlorinated biphenyl (Aroclor 1248); (Chlorodiphenyl (48% Cl)) | 12672-29-6 | 2315 |
15.01
15.02
4.10
11.01
3.05
7.11
3.02
3.10
3.07
5.00
|
|||||||||
| Formula | Synonyms | |||||||||||
| [Unspecified] | ARTICLES CONTAINING POLYCHLORINATED BIPHENYLS (PCB), A 1248, AROCHLOR, AROCLOR 1016, AROCLOR 1221, AROCLOR 1232, AROCLOR 1242, AROCLOR 1248, AROCLOR 1254, AROCLOR 1260, AROCLOR® 1254, ARTÍCULOS QUE CONTIENEN BIFENILOS POLICLORADOS (BPC) (DOT SP, BIFENILOS POLICLORADOS (DOT SPANISH), BPC (DOT FRENCH), BPC (DOT SPANISH), CHLORINATED BIPHENYL, DIPHÉNYLES POLYCHLORÉS (DOT FRENCH), HALOGENATED WAXES, OBJETS CONTENANT DES DIPHÉNYLES POLYCHLORÉS (PCB) (DOT FRENC, PCB, PCB (DOT FRENCH), PCBS, POLYCHLORINATED BIPHENYL, POLYCHLORINATED BIPHENYLS, POLYCHLOROPOLYPHENYLS, PCB-1248, CHLORODIPHENYL (48 PERCENT CL), POLYCHLORINATED BIPHENYL 1248 | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 288 | L | 25 | 1.4-1.5 |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 3.0 | 360 | 2200 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.25 | 31 | 190 |
Technical Basis
A review of available sources identified acute toxicity data (LD50, LDLo) for several species and routes. In addition, analysts evaluated exposure limits for the structurally similar chemical chlorodiphenyl - 42% chlorine (CASRN: 53469-21-9), an Aloclor with 48% chlorine, for TEEL development. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. Analysts determined that the use of the IDLH, which reports a combined value for polychlorinated biphenyls (PCBs) with 42% and 54% chlorine, is not advised considering that 54% PCBs are uniquely toxic among PCB congeners. Instead, analysts selected the available rat oral LD50 as the TEEL-3 basis. The TEEL-2 value was derived according to Table 3.5. The TLV-TWA for chlorodiphenyl – 42% chlorine (CASRN: 53469-21-9) was selected as the TEEL-1 basis (Section 3.4.6).
• PAC-1 = TEEL-1 = TLV-TWA (chlorodiphenyl – 42% chlorine, CASRN: 53469-21-9; 1 mg/m3) x 3
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Rat oral LD50 (11000 mg/kg)
This review generated a PAC-3 value consistent with Rev. 29A, and inconsistent PAC-2 and PAC-1 values. The Rev. 29A and current TEEL-3 source, and methodology are consistent. The Rev. 29A TEEL-2 basis was a rat TDLo not identified during the current review; instead, the current TEEL-2 was derived from the TEEL-3 (Table 3.5). The Rev. 29A TEEL-1 was derived from the TEEL-2, while the current TEEL-1 basis is a TLV-TWA for a similar chemical (chlorodiphenyl – 42% chlorine, CASRN: 53469-21-9, Section 3.4.6).
• PAC-1 = TEEL-1 = TLV-TWA (chlorodiphenyl – 42% chlorine, CASRN: 53469-21-9; 1 mg/m3) x 3
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Rat oral LD50 (11000 mg/kg)
This review generated a PAC-3 value consistent with Rev. 29A, and inconsistent PAC-2 and PAC-1 values. The Rev. 29A and current TEEL-3 source, and methodology are consistent. The Rev. 29A TEEL-2 basis was a rat TDLo not identified during the current review; instead, the current TEEL-2 was derived from the TEEL-3 (Table 3.5). The Rev. 29A TEEL-1 was derived from the TEEL-2, while the current TEEL-1 basis is a TLV-TWA for a similar chemical (chlorodiphenyl – 42% chlorine, CASRN: 53469-21-9, Section 3.4.6).
References
Chemical information retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/36400 and
FDA Status Report on the Chemistry and Toxicology of Polychlorinated Biphenyls (PCB) or Aroclors as of June 1, 1970. See Table 3. Retrieved from: https://cdn.toxicdocs.org/gw/gwZ1mO5gOwrZeYo20Rw0jK6a/gwZ1mO5gOwrZeYo20Rw0jK6a.pdf. These results are also reported in reference #3.
See Table 1. Fishbein, L. Annual Review of Pharmacology and Toxicology, Vol. 14, 1974, 139-159. Retrieved from: https://doi.org/10.1146/annurev.pa.14.040174.001035
R. Kimbrough, et al. Environmental Health Perspectives, 24, 1978. https://doi.org/10.1289/ehp.7824173
Rat LD50. Annual Review of Pharmacology., 14(139), 1974. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/36400
IDLH for chlorodiphenyls (42% chlorine and 54% chlorine, CASRN: 53469-21-9 and 11109-69-1 respectively). Retrieved from: https://www.cdc.gov/niosh/idlh/53469219.html
OSHA TWAs for Aroclor 1242 (chlorodiphenyl – 42% chlorine, CASRN: 53469-2): https://www.osha.gov/chemicaldata/392
TLV-TWA for Aroclor 1242 (chlorodiphenyl – 42% chlorine, CASRN: 53469-2): https://www.acgih.org/chlorodiphenyl-42-chlorine/