PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Polychlorinated biphenyl (Aroclor 1260/1262): (Chlorodiphenyl (61% Cl)) | z-0043 | 2315 |
15.01
15.02
4.05
8.00
4.06
4.07
2.00
7.11
3.05
3.02
|
|||||||||
| Formula | Synonyms | |||||||||||
| [Unspecified] | ||||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 0 | S | 1.44 @ 30°C |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 3.0 | 370 | 2200 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0 | 0 | 0 |
Technical Basis
This chemical is a mixture of Aloclor 1260 and 1262. A review of available sources did not identify exposure limits or acute toxicity data for this mixture. Instead, analysts evaluated acute toxicity data for Aloclor 1262 (LD50, LDLo) for several species and routes. In addition, analysts evaluated exposure limits for the structurally similar chemical chlorodiphenyl - 42% chlorine (CASRN: 53469-21-9) for TEEL development. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. Analysts determined that the use of the IDLH, which reports a combined value for polychlorinated biphenyls (PCBs) with 42% and 54% chlorine, is not advised considering that 54% PCBs are uniquely toxic among PCB congeners. Analysts observed that 1) animal strain and species influence toxic effects and 2) Aroclor 1260 is more toxic to immature rats than to adults. Considering this, analysts selected the lowest, adult rat oral LD50 for Aroclor 1260, a component of this mixture, as the TEEL-3 basis. The TEEL-2 value was derived according to Table 3.5. The TLV-TWA for chlorodiphenyl – 42% chlorine (CASRN: 53469-21-9) was selected as the TEEL-1 basis (Section 3.4.6).
• PAC-1 = TEEL-1 = TLV-TWA (chlorodiphenyl – 42% chlorine, CASRN: 53469-21-9; 1 mg/m3) x 3
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Rat oral LD50 (Aloclor 1262, CASRN: 37324-23-5, 11.3 g/kg)
This review generated PAC values inconsistent with Rev. 29A. The Rev. 29A TEEL-3 source was based on Aloclor 1262 oral LD50 toxicity in weanling rats; the current TEEL-3 is instead based on toxicity for adult rats. The Rev. 29A TEEL-2 basis was a rat TDLo not found during the current review; instead, the TEEL-2 was derived from the TEEL-3. The Rev. 29A TEEL-1 was derived from the TEEL-2, while the current TEEL-1 basis is a TLV-TWA for a similar chemical (chlorodiphenyl – 42% chlorine, CASRN: 53469-21-9, Section 3.4.6).
• PAC-1 = TEEL-1 = TLV-TWA (chlorodiphenyl – 42% chlorine, CASRN: 53469-21-9; 1 mg/m3) x 3
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Rat oral LD50 (Aloclor 1262, CASRN: 37324-23-5, 11.3 g/kg)
This review generated PAC values inconsistent with Rev. 29A. The Rev. 29A TEEL-3 source was based on Aloclor 1262 oral LD50 toxicity in weanling rats; the current TEEL-3 is instead based on toxicity for adult rats. The Rev. 29A TEEL-2 basis was a rat TDLo not found during the current review; instead, the TEEL-2 was derived from the TEEL-3. The Rev. 29A TEEL-1 was derived from the TEEL-2, while the current TEEL-1 basis is a TLV-TWA for a similar chemical (chlorodiphenyl – 42% chlorine, CASRN: 53469-21-9, Section 3.4.6).
References
General information on PCBs retrieved from: https://www.atsdr.cdc.gov/toxprofiles/tp17-c4.pdf
Rat LD50 for Aloclor 1262, CASRN: 37324-23-5. FDA Status Report on the Chemistry and Toxicology of Polychlorinated Biphenyls (PCB) or Aroclors as of June 1, 1970. See Table 3. Retrieved from: https://cdn.toxicdocs.org/gw/gwZ1mO5gOwrZeYo20Rw0jK6a/gwZ1mO5gOwrZeYo20Rw0jK6a.pdf . Also reported in reference #3.
Rat LD50 for Aloclor 1262, CASRN: 37324-23-5., see Table 1. Fishbein, L. Annual Review of Pharmacology and Toxicology, Vol. 14, 1974, 139-159. Retrieved from: https://doi.org/10.1146/annurev.pa.14.040174.001035
IDLH for chlorodiphenyls (42% chlorine and 54% chlorine, CASRN: 53469-21-9 and 11109-69-1 respectively). Retrieved from: https://www.cdc.gov/niosh/idlh/53469219.html
OSHA TWAs for Aroclor 1242 (chlorodiphenyl – 42% chlorine, CASRN: 53469-21-9): https://www.osha.gov/chemicaldata/392
TLV-TWA for Aroclor 1242 (chlorodiphenyl – 42% chlorine, CASRN: 53469-21-9): https://www.acgih.org/chlorodiphenyl-42-chlorine/