PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Polyisocyanate prepolymer | z-0115 |
11.01
15.01
15.02
9.00
7.01
4.01
11.00
4.07
|
||||||||||
| Formula | Synonyms | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 0 | S |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.15 | 5.0 | 55 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0 | 0 | 0 |
Technical Basis
A review of available sources did not identify exposure limits or toxicity data for polyisocyanate prepolymer; this chemical name does not give an adequate definition of this chemical, given that 1) “polyisocyanate prepolymers” describes a class of reactive chemical intermediates used in polyurethane synthesis and 2) that the CASRN listed (z-0115) does not correspond to a manufacturing number or specific polyisocyanate prepolymer. Considering this, two common types of polyisocyanate prepolymers used in manufacturing, toluene diisocyanates (TDI, 584-84-9) and methylene diphenyl diisocyanates (MDI, CASRN: 101-68-8), were considered. Records indicate that the chemical of interest was a solid and notes an MDI basis (refer to Rev. 24 PACs); therefore, MDI was selected for further TEEL development. A review of available sources identified exposure limits for MDI. Data sources were selected according to the hierarchy listed in Table 3.1. The ERPG-3 and ERPG-2 were selected as TEEL-3 and TEEL-2 values, due to their use priority (Section 2.1). The TLV-TWA was selected as the TEEL-1 basis.
• TEEL-1 = TLV-TWA (MDI, CASRN: 101-68-8, 0.005 ppm/0.05 mg/m3) x 3
• TEEL-2 = ERPG-2 (MDI, CASRN: 101-68-8)
• TEEL-3 = ERPG-3 (MDI, CASRN: 101-68-8)
This review generated TEEL-3 and TEEL-2 values that are consistent with Rev. 29A. The Rev. 29A TEEL-1 was derived from the TEEL-2, while the current TEEL-1 basis is a TLV-TWA.
• TEEL-1 = TLV-TWA (MDI, CASRN: 101-68-8, 0.005 ppm/0.05 mg/m3) x 3
• TEEL-2 = ERPG-2 (MDI, CASRN: 101-68-8)
• TEEL-3 = ERPG-3 (MDI, CASRN: 101-68-8)
This review generated TEEL-3 and TEEL-2 values that are consistent with Rev. 29A. The Rev. 29A TEEL-1 was derived from the TEEL-2, while the current TEEL-1 basis is a TLV-TWA.
References
Information about polyisocyanate prepolymers: https://archive.epa.gov/epa/sites/production/files/2015-06/documents/toxicology_including_appendix_a_a-1_a-2_for_the_revised_draft_of_the_isocyanates_profile.pdf
Information about polyisocyanate prepolymers: West RJ, Euskirchen L, Neuhahn A, Seneker S, Spence MW. Exploring structure/property relationships to health and environmental hazards of polymeric polyisocyanate prepolymer substances-1. Design of experiments, aquatic exposure, and acute aquatic toxicity. Toxicol Ind Health. 2022 Sep;38(9):544-555. doi: 10.1177/07482337221097009. Epub 2022 May 21. PMID: 35603521. https://pubmed.ncbi.nlm.nih.gov/35603521/
Information about TDI and MDI: https://www.atsdr.cdc.gov/ToxProfiles/tp206.pdf
Rev. 24, published 5/6/2008 retrieved from the PAC Archive: https://edms3.energy.gov/pac/Archive
ERPGs: https://cameochemicals.noaa.gov/chemical/8588
Exposure data: https://www.osha.gov/chemicaldata/23