PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Propanediamine, 1,2- | 78-90-0 | 2258 |
14.01
11.01
14.02
11.00
4.01
4.08
4.07
|
|||||||||
| Formula | Synonyms | |||||||||||
| C3H10N2 | 1,2-PROPYLENEDIAMINE, (.+-.)-1,2-DIAMINOPROPANE, (RS)-1,2-PROPANEDIAMINE, 1,2-DIAMINOPROPANE, 1,2-PROPANEDIAMINE, 1,2-PROPILENDIAMINA (DOT SPANISH), 1,3-PROPILENDIAMINA (DOT SPANISH), 1,3-PROPYLENEDIAMINE, 1-METHYL-1,2-DIAMINOETHANE, 2,3-DIAMINOPROPANE, DL-1,2-PROPANEDIAMINE, DL-1,2-PROPYLENEDIAMINE, PROPYLÈNE-1,2 DIAMINE (DOT FRENCH), PROPYLÈNE-1,3 DIAMINE (DOT FRENCH), PROPYLENEDIAMINE, PROPYLENEDIAMINE (DOT) | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 74.15 | L | 118.9 | 0.9 |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 3.9 | 43 | 260 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 1.3 | 14 | 86 |
Technical Basis
A review of available sources identified acute toxicity data (LD50) for various species and routes. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. The lowest reported rat oral LD50 dose was selected as the TEEL-3 basis. TEEL-2 and TEEL-1 values were derived according to Table 3.5.
• PAC-1 = TEEL-1 = TEEL-2/11
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Rat oral LD50 (1300 mg/kg)
This review generated PAC values inconsistent with Rev. 29A. The Rev. 29A TEEL-3 basis was a rat oral LD50 found in this review; however, the current review found and is a lower dose rat oral LD50. The Rev. 29A and current TEEL-2 and TEEL-1 methodology remains consistent, with differences in values due to the change of the TEEL-3 basis.
• PAC-1 = TEEL-1 = TEEL-2/11
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Rat oral LD50 (1300 mg/kg)
This review generated PAC values inconsistent with Rev. 29A. The Rev. 29A TEEL-3 basis was a rat oral LD50 found in this review; however, the current review found and is a lower dose rat oral LD50. The Rev. 29A and current TEEL-2 and TEEL-1 methodology remains consistent, with differences in values due to the change of the TEEL-3 basis.
References
Chemical information: https://pubchem.ncbi.nlm.nih.gov/compound/1_2-Diaminopropane.
Rat oral LD50 (1300 mg/kg). https://chem.echa.europa.eu/100.001.051/dossier-view/34b3e23d-8653-466c-83bd-15ee5ff90397/17ff91c8-0041-4e05-a226-83d589d07168_e637a86e-dbff-4c6d-a1c1-05ffb6c448d7?searchText=78-90-0
Rat oral LD50 (2230 mg/kg). Union Carbide Data Sheet., 3/12/1969. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/1_2-Diaminopropane.