PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Propionyl chloride | 79-03-8 | 1815 |
14.01
11.01
14.02
4.07
|
|||||||||
| Formula | Synonyms | |||||||||||
| CH3CH2CO.Cl | PROPIONYL CHLORIDE, CHLORO ETHYL KETONE, CHLORURE DE PROPIONYLE (DOT FRENCH), CLORURO DE PROPIONILO (DOT SPANISH), PROPIONIC ACID CHLORIDE | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 92.53 | L | -94 | 80 | 1.065 |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.13 | 1.5 | 8.8 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.034 | 0.40 | 2.3 |
Technical Basis
A review of available sources identified rat and mouse toxicity data (LC50, LD50) for oral, inhalation, and intraperitoneal routes. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. The most preferred species and exposure data, a rat LC50, was selected as the TEEL-3 basis and was ¬¬-scaled to a 60-minute equivalent using the ten Berge equation (Section 3.3.4). TEEL-1 and TEEL-2 values were derived according to Table 3.5.
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = Rat LC50 (200 mg/m3/4H)
This review generated TEEL values inconsistent with Rev. 29A. The Rev. 29A TEEL-3 was also based on a rat LC50; however, that data, 75 mg/m3/4H, was not located in this review. The TEEL-2 and TEEL-1 methodologies remain consistent with differences in values due to the change of the TEEL-3 basis.
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = Rat LC50 (200 mg/m3/4H)
This review generated TEEL values inconsistent with Rev. 29A. The Rev. 29A TEEL-3 was also based on a rat LC50; however, that data, 75 mg/m3/4H, was not located in this review. The TEEL-2 and TEEL-1 methodologies remain consistent with differences in values due to the change of the TEEL-3 basis.
References
Chemical information: https://pubchem.ncbi.nlm.nih.gov/compound/Propionyl-chloride
Rat LC50 (200 mg/m3/4H): European Chemicals Agency (ECHA); Registered Substances, propionyl chloride (CAS Number 79-03-8) (EC Number: 201-170-0) (Last updated: April 27, 2017): https://echa.europa.eu/brief-profile/-/briefprofile/100.001.064 (Click Scientific Properties Tab).