PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Prothoate; (Isopropyl diethyldithiophosphorylacetamide) | 2275-18-5 |
4.05
7.01
8.00
7.00
4.01
11.00
4.07
3.08
3.05
7.11
|
||||||||||
| Formula | Synonyms | |||||||||||
| C9H20NO3PS2 | PROTHOATE, AC 18682, ACETAMIDE, N-ISOPROPYL-2-MERCAPTO-, S-ESTER WITH O,O-DIETHYL, AMERICAN CYANAMID 18,682, EI 18682, ENT 24,652, FAC, FAC (PESTICIDE), FAC 20, FAK 40, FAK-40, FOSTION, ISOPROPYL DIETHYLDITHIOPHOSPHORYLACETAMIDE, L 343, N-MONOISOPROPYLAMIDE OF O,O-DIETHYLDITHIOPHOSPHORYLACETIC AC, O,O-DIETHYL PHOSPHORODITHIOATE S-ESTER WITH N-ISOPROPYL-2-ME, O,O-DIETHYL S-(N-ISOPROPYLCARBAMOYL- METHYL) DITHIOPHOSPHATE, O,O-DIETHYL S-(N-ISOPROPYLCARBAMOYLMETHYL) PHOSPHORODITHIOAT, O,O-DIETHYL S-ISOPROPYLCARBAMOYLMETHYL PHOSPHORODITHIOATE, O,O-DIETHYLDITHIOPHOSPHORYLACETIC ACID, N-MONOISOPROPYLAMIDE, OLEOFAC, PHOSPHORODITHIOIC ACID, O,O-DIETHYL ESTER, S-ESTER WITH N-IS, PHOSPHORODITHIOIC ACID, O,O-DIETHYL ESTER, S-ESTER WITH N-IS, PHOSPHORODITHIOIC ACID, O,O-DIETHYL S-(2-((1-METHYLETHYL) AM, PROTHOAT, TELEFOS, TRIMETHOATE | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 285.39 | S | 28.5 | 330 | 0.0001 | 25 |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.15 | 1.7 | 7.3 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.013 | 0.15 | 0.63 |
Technical Basis
A review of available sources identified a LOC and acute toxicity data (LC50, LD50) for several routes and species. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. The most preferred species and route, a rat LC50, was selected as the TEEL-3 basis and it was scaled to a 60-minute equivalent using the ten Berge equation (Section 3.3.4). The LOC was selected as the TEEL-2. The TEEL-1 value were derived according to Table 3.5.
• PAC-1 = TEEL-1 = TEEL-2/11
• PAC-2 = TEEL-2 = LOC (0.0017 g/m3)
• PAC-3 = TEEL-3 = Rat LC50 (165 mg/m3/4H)
This review generated PAC-2 and PAC-1 values consistent with Rev. 29A and a PAC-3 inconsistent with Rev. 29A. The Rev. 29A TEEL-3 was derived from the TEEL-2, while the current TEEL-3 basis is a rat LC50 for prothoate, a high priority source (Table 3.1).
• PAC-1 = TEEL-1 = TEEL-2/11
• PAC-2 = TEEL-2 = LOC (0.0017 g/m3)
• PAC-3 = TEEL-3 = Rat LC50 (165 mg/m3/4H)
This review generated PAC-2 and PAC-1 values consistent with Rev. 29A and a PAC-3 inconsistent with Rev. 29A. The Rev. 29A TEEL-3 was derived from the TEEL-2, while the current TEEL-3 basis is a rat LC50 for prothoate, a high priority source (Table 3.1).
References
Chemical information: https://pubchem.ncbi.nlm.nih.gov/compound/16774
Rat LC50. Egeszsegtudomany., 24(173), 1980. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/16774
LOC. Appendix C, pg. C-8. https://www.epa.gov/sites/default/files/2015-09/documents/technical_guidance_for_hazard_analysis.pdf