PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Pyrethrin 1; (Cyclopropaneacrylic acid, 2,2-dimethyl-3-(2-methylpropenyl)-, ester with 4-hydroxy-3-methyl-2-(2,4-pentadienyl)-2-cyclopenten-1-one) | 121-21-1 |
7.01
11.00
8.00
4.08
4.07
9.00
3.11
11.01
15.01
|
||||||||||
| Formula | Synonyms | |||||||||||
| C21.H28.O3 | ||||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 328.49 | L | 0.0000203 | 1.5192 @ 18°C |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 1.1 | 1.9 | 11 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 15 | 26 | 150 |
Technical Basis
A review of available data sources identified the following: TLV-TWA1, LD50 (rat2-4) and LC505 for inhalation and oral routes. Each was evaluated using the guidelines for calculating equivalent values in the TEEL Handbook. A duration of 1 day was assumed for LCeq calculations, where not specified. Toxicity data were evaluated for their relative preference ranking (Section 3.3.2, Table 3.1). The rat LC50 data is the most preferred and was selected to estimate a TEEL-3 value and time-scaled to a 60-minute equivalent using the ten Berge equation (Section 3.3.4). A TEEL-2 was calculated from the TEEL-3 value, according to Table 3.5. The TLV-TWA was used to estimated TEEL-1 value.
• TEEL-1 = TLV-TWA x 3
• TEEL-2 = TEEL-3/6
• TEEL-3 = Estimated from 4-hrs rat LC50 (3400 mg/m3)
This review generated TEEL values consistent with those published in Rev. 29A.
• TEEL-1 = TLV-TWA x 3
• TEEL-2 = TEEL-3/6
• TEEL-3 = Estimated from 4-hrs rat LC50 (3400 mg/m3)
This review generated TEEL values consistent with those published in Rev. 29A.
References
TLV-TWA; https://pubchem.ncbi.nlm.nih.gov/source/hsdb/6302#section=OSHA-Standards-(Complete)
Rat, oral LD50: EFSA; via CompTox: https://comptox.epa.gov/dashboard/chemical/hazard/DTXSID4034499
Rat, oral LD50: EPA ORD; via CompTox: https://comptox.epa.gov/dashboard/chemical/hazard/DTXSID4034499
Rat, oral LD50: Pesticide Biochemistry and Physiology., 2(308), 1972; via PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/5281045#section=Acute-Effects
Rat, oral 4-hrs LC50: Tomlin, C.D.S. (ed.). The Pesticide Manual - World Compendium. 10th ed. Surrey, UK: The British Crop Protection Council, 1994., p. 878; via PubChem: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/6302#section=Non-Human-Toxicity-Values-(Complete)