PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Pyriminil; (Pyriminyl) | 53558-25-1 |
4.08
4.05
4.01
7.01
8.00
7.00
11.00
4.09
4.10
4.07
|
||||||||||
| Formula | Synonyms | |||||||||||
| C13H12N4O3 | PYRIMINIL, DLP 787, DLP-87, N-(4-NITROPHENYL)-N^-(3- PYRIDINYLMETHYL)UREA, N-3-PYRIDYLMETHYL-N'-P-NITROPHENYLUREA, PYRIMINYL, PYRINURON, RH 787, RH-787, UREA, 1-NITROPHENYL-3-(3-PYRIDYLMETHYL)-, UREA, N-(4-NITROPHENYL)-N'-(3-PYRIDINYLMETHYL)-, VACOR | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 272.29 | S | 0.00001 | 25 |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.52 | 5.8 | 35 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 5.8 | 65 | 390 |
Technical Basis
A review of available data sources identified the following: LD50 (dog1, monkey2, mouse3, rat4,) LDLo5, and TDLo6 for oral routes. Each was evaluated using the guidelines for calculating equivalent values in the TEEL Handbook. A duration of 1 day was assumed for LCeq calculations.
Toxicity data were evaluated for their relative preference ranking7. Human toxicity data were evaluated but not selected, due to more current sources that are also more statistically valid (Section 3.3.1). The monkey, oral LD50 data was the most preferred among remaining sources and was selected to estimate a TEEL-3 value. TEEL-2 and TEEL-1 values were calculated from the TEEL-3 value, according to Table 3.5.
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = Estimated from monkey, oral LD50 (2000 mg/kg)
This review generated two TEEL values inconsistent with those published in Rev. 29A due to a different starting point.
Toxicity data were evaluated for their relative preference ranking7. Human toxicity data were evaluated but not selected, due to more current sources that are also more statistically valid (Section 3.3.1). The monkey, oral LD50 data was the most preferred among remaining sources and was selected to estimate a TEEL-3 value. TEEL-2 and TEEL-1 values were calculated from the TEEL-3 value, according to Table 3.5.
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = Estimated from monkey, oral LD50 (2000 mg/kg)
This review generated two TEEL values inconsistent with those published in Rev. 29A due to a different starting point.
References
Dog, oral LD50: Krieger, R. (ed.). Handbook of Pesticide Toxicology. Volume 2, 2nd ed. 2001. Academic Press, San Diego, California., p. 1803; via PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/40813#section=Acute-Effects
Monkey, oral LD50: Krieger, R. (ed.). Handbook of Pesticide Toxicology. Volume 2, 2nd ed. 2001. Academic Press, San Diego, California., p. 1803; via PubChem: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/6460#section=Non-Human-Toxicity-Values-(Complete)
Mouse, oral LD50: Lewis, R.J. Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996., p. 2842; via PubChem: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/6460#section=Non-Human-Toxicity-Values-(Complete)
Rat, oral LD50: Journal of Hygiene., 80(401), 1978 [PMID:649948]; via PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/40813#section=Acute-Effects
Human male, oral LDLo: New England Journal of Medicine., 302(73), 1980 [PMID:6243167]; via PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/40813#section=Acute-Effects
Human male, oral TDLo: Clinical Toxicology., 18(441), 1981 [PMID:6263541]; via PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/40813#section=Acute-Effects
Species and route are ranked according to the preferences stated in Section 3.3.2, while the data selection hierarchy from Table 3.1.