Technical Basis
A review of available sources did not identify exposure limits or acute toxicity data for barium permanganate. Analysts evaluated a structurally similar compound, potassium permanganate (KMnO4, CASRN: 7722-64-7) according to Section 3.4.6.
A review of available sources for potassium permanganate identified human (TDLo, LDLo) and animal (LDLo, LD50) acute toxicity data. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. The human (female) oral LDLo was selected as the TEEL-3 basis. The human oral TDLo, reported endpoints that would impede escape (nausea, vomiting); therefore, it was selected as the TEEL-2 basis. The TEEL-1 value was derived according to Table 3.5. These were selected as the TEELs for ammonium permanganate.
• TEEL-1 = TEEL-2/11
• TEEL-2 = Human (female) oral TDLo (potassium permanganate, CASRN: 7722-64-7; 2.4 mg/kg; endpoints: nausea, vomiting)
• TEEL-3 = Human (female) oral LDLo (potassium permanganate, CASRN: 7722-64-7; 100 mg/kg)
This review generated TEEL values inconsistent with Rev. 29A. The Rev. 29A TEEL-2 and TEEL-1 bases were molecular weight adjusted REL-STEL and REL-C for manganese (CASRN: 7439-96-5), respectively. The current TEELs were derived for a structurally similar chemical, potassium permanganate, which shares strong oxidative properties with barium permanganate
References
Chemical information: https://pubchem.ncbi.nlm.nih.gov/compound/Barium-permanganate.
Women oral TDLo for potassium permanganate (CASRN: 7722-64-7). Archives Internationales de Pharmacodynamie et de Therapie., 44(446), 1933. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/Potassium-Permanganate
Women oral LDLo (100 mg/kg) for potassium permanganate (CASRN: 7722-64-7). Human & Experimental Toxicology., 15(259), 1996 [PMID:8839216]. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/Potassium-Permanganate