PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Pyrrolidinone, 2- | 616-45-5 |
15.01
4.01
4.05
7.01
7.00
11.00
3.09
3.02
3.01
5.10
|
||||||||||
| Formula | Synonyms | |||||||||||
| C4-H7-N-O | ||||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 85.12 | S | 24.6 | 245 | 0.00949 | 25 | 1.116 |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 15 | 170 | 990 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 4.3 | 49 | 280 |
Technical Basis
A review of available sources identified the following: LC50 and LD50 (rat, guinea pig) for oral and intraperitoneal routes. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. Although the most preferred route, the LC50 was removed from consideration due to an unverifiable source (Section 3.3.1). Of the remaining animal toxicity data, the most recent rat oral LD50 (2014) was selected as the TEEL-3 basis. TEEL-2 and TEEL-1 values were derived according to Table 3.5.
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = Rat oral LD50 (>5000 mg/kg)
This review generated TEEL values that are more conservative than those in Rev. 29A due to a change in TEEL-3 basis. The Rev. 29A TEEL-3 source, a rat LD50, was found during research; however, the current TEEL-3 basis was selected because it is both a more recent source and more conservative value (Section 3.3.1). The Rev. 29A and current TEEL-2 and TEEL-1 methodology remains unchanged (derived from TEEL-3, according to Table 3.5).
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = Rat oral LD50 (>5000 mg/kg)
This review generated TEEL values that are more conservative than those in Rev. 29A due to a change in TEEL-3 basis. The Rev. 29A TEEL-3 source, a rat LD50, was found during research; however, the current TEEL-3 basis was selected because it is both a more recent source and more conservative value (Section 3.3.1). The Rev. 29A and current TEEL-2 and TEEL-1 methodology remains unchanged (derived from TEEL-3, according to Table 3.5).
References
https://pubchem.ncbi.nlm.nih.gov/compound/2-Pyrrolidinone
https://pubchem.ncbi.nlm.nih.gov/source/hsdb/2652
Rat oral LD50, >5000 mg/kg; Table 3, pg. 13. “Characterization Screening-level Hazard Characterization Sponsored Chemical 2-Pyrrolidone (CASRN 616-45-5) Supporting Chemical 1-Methyl-2-pyrrolidone (CASRN 872-50-4)”; EPA (2014). Retrieved from: https://nepis.epa.gov/Exe/ZyNET.exe/P1014ILY.TXT?ZyActionD=ZyDocument&Client=EPA&Index=2011+Thru+2015&Docs=&Query=&Time=&EndTime=&SearchMethod=1&TocRestrict=n&Toc=&TocEntry=&QField=&QFieldYear=&QFieldMonth=&QFieldDay=&IntQFieldOp=0&ExtQFieldOp=0&XmlQuery=&File=D%3A%5Czyfiles%5CIndex%20Data%5C11thru15%5CTxt%5C00000040%5CP1014ILY.txt&User=ANONYMOUS&Password=anonymous&SortMethod=h%7C-&MaximumDocuments=1&FuzzyDegree=0&ImageQuality=r75g8/r75g8/x150y150g16/i425&Display=hpfr&DefSeekPage=x&SearchBack=ZyActionL&Back=ZyActionS&BackDesc=Results%20page&MaximumPages=1&ZyEntry=1&SeekPage=x&ZyPURL