PAC Database - Detailed Chemical Data

Chemical Identity
Chemical CAS# UN# Health Code Numbers
Saxitoxin 35523-89-8
7.01
11.00
Formula Synonyms
C10.H17.N7.O4
Physical Properties
Mol Wt State MP (°C) BP (°C) VP (Hg) VP (°C) SG LEL (ppm)
299.34 S
PAC Values
PAC Values (Original Units: mg/m3)
PAC-1 PAC-2 PAC-3
0.000021 0.00023 0.0014
Converted PAC Values (ppm)
PAC-1 PAC-2 PAC-3
0.0000017 0.000019 0.00011
Technical Basis
A review of available sources identified acute toxicity data (LD50) for several species and routes. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.6.2, 3.6.3, 3.6.4, and evaluated using factors in Tables 3.2, 3.3, and 3.4. Inhalation exposures were scaled to 60-minute equivalents using the ten Berge equation (Section 3.3.4). The most preferred route acute toxicity, a mouse LC50, was selected as the TEEL-3 basis. TEEL-2 and TEEL-1 values were derived according to Table 3.5.
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = Mouse LC50 (0.3 µg/L/10M)
This review generated TEEL values consistent with Rev. 29A.
References
https://ncithesaurus.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C163698
Monkey oral LD50 (364 µg/kg). Therapie., 24(191), 1969 [PMID:5807421]. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/Saxitoxin.
Mouse LC¬50 (300 µg/m3/24H). National Technical Information Service., AD-A203-563. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/Saxitoxin.
Mouse LC50 0.3 mg/m3/10M: Creasia D.A., et. al. Acute Inhalation Toxicity of Saxitoxin to Mice. National Technical Information Service. AD-A203-563. Research at Fort Detrick, MD. Available at: https://apps.dtic.mil/sti/tr/pdf/ADA203563.pdf
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PAC values marked with a subscript "A" correspond to 60-minute AEGL values.
PAC values marked with a subscript "E" correspond to ERPG values.
PAC values marked by * are >= 10% lower explosive limit (LEL) but < 50% LEL.
PAC values marked by ** are > 50% LEL but < 100% LEL.
PAC values marked by *** are >= LEL.