PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Benzamide | 55-21-0 |
15.01
4.01
11.01
4.04
7.00
4.07
7.01
|
||||||||||
| Formula | Synonyms | |||||||||||
| C7.H7.N.O | BENZAMIDE, BENZENECARBOXAMIDE, BENZOIC ACID AMIDE, BENZOYLAMIDE, PHENYLCARBOXAMIDE, PHENYLCARBOXYAMIDE | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 121.15 | S | 130 | 288 | 0.000165 | 1.341 |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 1.9 | 21 | 130 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.38 | 4.2 | 26 |
Technical Basis
A review of available sources identified rat and mouse LD50 toxicity data for oral and intraperitoneal routes. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. The LD50 of the most preferred route, a mouse oral LD50, was selected as the TEEL-3 basis. TEEL-1 and TEEL-2 values were derived according to Table 3.5.
• PAC-1 = TEEL-1 = TEEL-2/11
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Mouse oral LD50 (1160 mg/kg)
This review generated PAC values inconsistent with Rev. 29A. The Rev. 29A TEEL-3 basis was a rat intraperitoneal LD50, while the current basis is a mouse oral LD50, a more preferred route data (oral > intraperitoneal, Section 3.3.2) that yielded a more conservative value. The Rev. 29A and current TEEL-2 and TEEL-1 methodology remains consistent, with differences in values due to the change of the TEEL-3 basis.
• PAC-1 = TEEL-1 = TEEL-2/11
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Mouse oral LD50 (1160 mg/kg)
This review generated PAC values inconsistent with Rev. 29A. The Rev. 29A TEEL-3 basis was a rat intraperitoneal LD50, while the current basis is a mouse oral LD50, a more preferred route data (oral > intraperitoneal, Section 3.3.2) that yielded a more conservative value. The Rev. 29A and current TEEL-2 and TEEL-1 methodology remains consistent, with differences in values due to the change of the TEEL-3 basis.
References
Chemical information: https://pubchem.ncbi.nlm.nih.gov/compound/Benzamide.
Mouse oral LD50: Toxicology and Applied Pharmacology., 19(20), 1971 [PMID:5570565]. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/Benzamide.