A review of available sources identified acute toxicity data (LD50) for various species and routes. In addition, analysts evaluated exposure limits for tin, inorganic compounds (TWAs; CASRN: 7440-31-5) for TEEL development. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. The most preferred species and route data, a rat oral LD50, was selected as the TEEL-3 basis. The TEEL-2 was derived according to Table 3.5. The tin, inorganic compounds TLV-TWA was selected as the TEEL-1 basis and a compound adjustment factor was applied (Section 3.2.2).
• PAC-1 = TEEL-1 = MW-adjusted TLV-TWA (tin, inorganic compounds, 2 mg/m3) x 3
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Rat oral LD50 (3457 mg/kg)
This review generated PAC values inconsistent with Rev. 29A. The Rev. 29A TEEL-3 basis was the MW-adjusted IDLH (1990) for inorganic tin (CASRN: 7440-31-5), while the current basis is a rat oral LD50 for sodium stannate. The Rev. 29A and current TEEL-2 methodology remains consistent, with differences in values due to the change of the TEEL-3 basis. The Rev. 29A and current TEEL-1 basis remains consistent; therefore, minor differences in values may be due to rounding.