PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Benzophenone | 119-61-9 |
15.01
11.01
15.02
7.01
8.00
11.00
4.10
4.07
3.09
3.02
|
||||||||||
| Formula | Synonyms | |||||||||||
| C13H10O | BENZOPHENONE, ADJUTAN 6016, ALPHA-OXODIPHENYLMETHANE, ALPHA-OXODITANE, BENZENE, BENZOYL-, BENZOYL BENZENE, BENZOYLBENZENE, DIPHENYL KETONE, DIPHENYL METHANONE, DIPHENYLMETHANONE, KAYACURE BP, PHENYL KETONE | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 182.23 | S | 49 | 305.4 | 1 | 108.2 | 1.1 |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 1.5 | 63 | 380 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.20 | 8.5 | 51 |
Technical Basis
A review of available sources identified an WEEL-TWA and acute toxicity data (LD50, LDLo) for several species and routes. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. The lowest dose rat oral LD50 was selected as the TEEL-3 basis. The TEEL-2 value was derived according to Table 3.5. The TWA was selected as the TEEL-1 basis.
• TEEL-1 = WEEL-TWA (0.5 mg/m3) x 3
• TEEL-2 = TEEL-3/6
• TEEL-3 = Rat oral LD50 (1900 mg/kg)
This review generated TEEL-3 and TEEL-2 values inconsistent with Rev. 29A. The Rev. 29A TEEL-3 basis was a mouse oral LD50, while the current basis is a more preferred species (rat > mouse). The Rev. 29A TEEL-2 basis was a rat TDLo not found during the current review; instead, the TEEL-2 was derived from the TEEL-3 (Table 3.5).
• TEEL-1 = WEEL-TWA (0.5 mg/m3) x 3
• TEEL-2 = TEEL-3/6
• TEEL-3 = Rat oral LD50 (1900 mg/kg)
This review generated TEEL-3 and TEEL-2 values inconsistent with Rev. 29A. The Rev. 29A TEEL-3 basis was a mouse oral LD50, while the current basis is a more preferred species (rat > mouse). The Rev. 29A TEEL-2 basis was a rat TDLo not found during the current review; instead, the TEEL-2 was derived from the TEEL-3 (Table 3.5).
References
TWA: https://tera.org/OARS/
Chemical information: https://pubchem.ncbi.nlm.nih.gov/compound/Benzophenone.
Rat oral LD50 (1900 mg/kg). DHHS/NTP; Toxicology and Carcinogenesis Studies of Benzophenone (CAS No. 119-61-9) Toxicity Report Series No. 61 NIH Pub No. 00-3943. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/Benzophenone.