PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Tetracycline hydrochloride | 64-75-5 |
11.00
4.06
4.10
4.07
4.03
3.02
3.10
5.00
5.10
|
||||||||||
| Formula | Synonyms | |||||||||||
| C22H24N2O8.ClH | TETRACYCLINE HYDROCHLORIDE, 2-NAPHTHACENECARBOXAMIDE, 4-(DIMETHYLAMINO)-1,4,4A,5,5A,6,11, 2-NAPHTHACENECARBOXAMIDE, 4-(DIMETHYLAMINO)-1,4,4A,5,5A,6,11, 4-(DIMETHYLAMINO)-1,4,4A,5,5A,6,11,12A-OCTAHYDRO-3,6,10,12,1, ACHRO, ACHROMYCIN HYDROCHLORIDE, ACHROMYCIN V, ALA TET, AMBRACYN, ARTROMYCIN, BRISTACICLINA, BRISTACYCLINE, CANCYCLINE-250, CEFRACYCLINE TABLETS, CYCLOPAR, DIACYCLINE, DUMOCYCLIN, FERMENTMYCIN, HOSTACYCLIN, HOSTACYCLINE, HYDROXY-6-METHYL-1,11-DIOXO-2-NAPHTHACENECARBOXAMIDE, MONO-H, MEDAMYCIN, MEPHACYCLIN, NCI-C55561, NEOCYCLINE B, PALTET, PANMYCIN, PANMYCIN HYDROCHLORIDE, PARTREX, POLYCYCLINE HYDROCHLORIDE, POLYOTIC OINTMENT, QUADRACYCLINE, SANCLOMYCINE, STECLIN, STECLIN HYDROCHLORIDE, SUBAMYCIN, SUPRAMYCIN, TET-CY, TETRABID, TETRACAPS, TETRACYCLINE CHLORIDE, TETRACYCLINE CHLOROHYDRATE, TETRACYN, U-5965, UNIMYCIN | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 280.94 | S |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 19 | 210 | 1300 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 1.7 | 18 | 110 |
Technical Basis
A review of available data sources identified the following: LD50 rat and mouse oral toxicity values as well as rat and mouse intravenous toxicity values. Toxicity data were selected according to the type of exposure, species, and route hierarchies stated in Sections 3.3.1, 3.3.2. The rat oral LD50 was selected as the TEEL-3 basis, as the most preferred species and route. TEEL-2 and TEEL-1 values were derived according to Table 3.5.
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = Rat oral LD50 (6443 mg/kg)
This review generated TEEL values consistent with those reported in Rev. 29A.
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = Rat oral LD50 (6443 mg/kg)
This review generated TEEL values consistent with those reported in Rev. 29A.
References
Rat, oral LD50: Thermo Fisher Scientific SDS: https://www.fishersci.com/store/msds?partNumber=AC233100025&productDescription=TETRACYCLINE+HYDROCHLORI+2.5GR&vendorId=VN00032119&countryCode=US&language=en
Rat and mouse oral LD50, and rat and mouse intravenous LD50: Merck SDS: https://www.merck.com/docs/product/safety-data-sheets/ah-sds/Tetracycline%20Hydrochloride%20Formulation_AH_MX_EN.pdf