PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Tetramethylammonium chloride | 75-57-0 |
15.01
11.01
15.02
4.08
4.05
8.00
7.00
11.00
7.01
4.01
|
||||||||||
| Formula | Synonyms | |||||||||||
| C4.H12.N.Cl | ||||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 109.62 | S hygr. |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.14 | 1.6 | 9.3 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.031 | 0.36 | 2.1 |
Technical Basis
A review of available sources identified acute toxicity data (LD50, LDLo) for several species and routes. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. The lowest dose rat oral LD50 was selected as the TEEL-3 basis (47 mg/kg). TEEL-2 and TEEL-1 values were derived according to Table 3.5.
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = Rat oral LD50 (47 mg/kg)
This review generated TEEL values inconsistent with Rev. 29A. The Rev. 29A and current TEEL-3 bases are consistent, rat oral LD50; however, the current dose is less than the Rev. 29A (47 mg/kg vs. 50 mg/kg). The Rev. 29A and current TEEL-2/TEEL-1 values were derived using the same methodology (Table 3.5), with differences due to the change in TEEL-3.
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = Rat oral LD50 (47 mg/kg)
This review generated TEEL values inconsistent with Rev. 29A. The Rev. 29A and current TEEL-3 bases are consistent, rat oral LD50; however, the current dose is less than the Rev. 29A (47 mg/kg vs. 50 mg/kg). The Rev. 29A and current TEEL-2/TEEL-1 values were derived using the same methodology (Table 3.5), with differences due to the change in TEEL-3.
References
Chemical description and acute toxicity data: https://pubchem.ncbi.nlm.nih.gov/compound/Tetramethylammonium-chloride.
Rat oral LD50 (47 mg/kg), retrieved from: https://chem.echa.europa.eu/100.000.801/dossier-view/aa18248c-c429-453a-a23c-2c009cb41ac8/IUC5-8c519577-ed5a-4256-9b58-1df925e03b79_ee37771c-db24-4317-b641-7d2f4bde94ee?searchText=75-57-0