PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Tetramethylammonium hydroxide | 75-59-2 | 1835 |
14.01
11.01
14.02
4.08
4.07
7.11
10.00
4.11
|
|||||||||
| Formula | Synonyms | |||||||||||
| C4H13NO | TETRAMETHYLAMMONIUM HYDROXIDE, AMMONIUM, TETRAMETHYL-, HYDROXIDE, HIDRÓXIDO DE TETRAMETILAMONIO (DOT SPANISH), HYDROXYDE DE TÉTRAMÉTHYLAMMONIUM (DOT FRENCH), MEGAPOSIT CD 14, NMD 3, NMW-W, OCG 945, OCG-OPD 262, OPD 262, TMAH, TOKUSO SD 20 | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 91.18 | L | 1 |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.0086 | 0.095 | 0.57 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.0023 | 0.025 | 0.15 |
Technical Basis
Toxicity data is limited for TMAH. A rat dermal LD50 was selected for TEEL-3 development (most preferable based on Sections 3.3.1, 3.3.2). Independent data is not available for TEEL-2 or TEEL-1; these are derived according to Table 3.5.
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = Rat dermal LD50 (28.7 mg/kg, 25% solution)
This review generated TEEL values that are inconsistent with Rev. 29A. Previously, a rabbit intravenous LDLo was used for TEEL-3. Considering source credibility/age, species priority, and conservatism (Section 3.3), the rat data is preferable.
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = Rat dermal LD50 (28.7 mg/kg, 25% solution)
This review generated TEEL values that are inconsistent with Rev. 29A. Previously, a rabbit intravenous LDLo was used for TEEL-3. Considering source credibility/age, species priority, and conservatism (Section 3.3), the rat data is preferable.
References
https://cameochemicals.noaa.gov/chemical/4610
Lee CH et al; Toxicol Ind Health 27 (6): 497-503 (2011); https://pubmed.ncbi.nlm.nih.gov/21310775/
Structure and Pharmacodynamic Activity of Drugs of the Vegetative Nervous System, Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948; via PubChem; National Center for Biotechnology Information (2023). PubChem Compound Summary for CID 60966, Tetramethylammonium hydroxide. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Tetramethylammonium-hydroxide