PAC Database - Detailed Chemical Data

Chemical Identity
Chemical CAS# UN# Health Code Numbers
Thiourea 62-56-6 2811
15.01
11.01
4.06
4.04
2.00
3.05
10.00
3.02
3.04
3.10
Formula Synonyms
CH4N2S THIOUREA, 2-THIOUREA, BETA-THIOPSEUDOUREA, ISOTHIOUREA, PSEUDOTHIOUREA, PSEUDOUREA, 2-THIO-, SULOUREA, THIOCARBAMIDE, THU, TSIZP 34, UREA, THIO-
Physical Properties
Mol Wt State MP (°C) BP (°C) VP (Hg) VP (°C) SG LEL (ppm)
76.12 S 178 25 1.405
PAC Values
PAC Values (Original Units: mg/m3)
PAC-1 PAC-2 PAC-3
0.38 4.1 25
Converted PAC Values (ppm)
PAC-1 PAC-2 PAC-3
0.12 1.3 8.0
Technical Basis
A review of available sources identified acute toxicity data (TDLo, LDLo, LD50) for several species and routes. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. The most preferred route and species data, a rat oral LD50, was selected as the TEEL-3 basis. Although there was an available human oral TDLo, it was not selected as the TEEL-2 basis because 1) the severity of the symptoms was not reported (blood hemorrhage and granulocytopenia can range from severe or non-severe in humans), 2) the duration was long (5 weeks), and 3) the resulting TEEL-2 would be higher than the TEEL-3. Instead, TEEL-2 and TEEL-1 values were derived according to Table 3.5.
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = Rat oral LD50 (125 mg/kg)
This review generated TEEL values that are consistent with Rev. 29A
References
Chemical info: https://pubchem.ncbi.nlm.nih.gov/compound/Thiourea
Rat oral LD50 125 mg/kg. Handbook of Toxicology, 4 vols., Philadelphia, W.B. Saunders Co., 1956-59, 5(177), 1959. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/Thiourea
Women oral TDLo¬ (1660 mg/kg/5W, toxicity endpoints: blood hemorrhage and granulocytopenia. Lancet., 246(179), 1944. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/Thiourea
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PAC values marked with a subscript "A" correspond to 60-minute AEGL values.
PAC values marked with a subscript "E" correspond to ERPG values.
PAC values marked by * are >= 10% lower explosive limit (LEL) but < 50% LEL.
PAC values marked by ** are > 50% LEL but < 100% LEL.
PAC values marked by *** are >= LEL.