Technical Basis
A review of available sources identified acute toxicity data (LD50) for various species (mouse, guinea pig) and routes (oral, intraperitoneal). Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. The most preferred species and route data, a mouse oral LD50, was selected as the TEEL-3 basis. TEEL-2 and TEEL-1 values were derived according to Table 3.5.
• PAC-1 = TEEL-1 = TEEL-2/11
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Mouse oral LD50 (4294 mg/kg)
This review generated PAC values consistent with Rev. 29A*.
References
Chemical information: https://pubchem.ncbi.nlm.nih.gov/compound/Thulium-chloride.
Chemical phase information: https://www.chemicalbook.com/ChemicalProductProperty_US_CB8227524.aspx
Mouse oral LD50: Environmental Quality and Safety, Supplement., 1(1), 1975 [PMID:1057514]. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/Thulium-chloride