PAC Database - Detailed Chemical Data

Chemical Identity
Chemical CAS# UN# Health Code Numbers
Toluenesulfonamide, p-; (Pasam) 70-55-3
4.11
5.10
3.10
7.01
8.00
Formula Synonyms
C7.H9.N.O2.S
Physical Properties
Mol Wt State MP (°C) BP (°C) VP (Hg) VP (°C) SG LEL (ppm)
171.23 0.000096 25
PAC Values
PAC Values (Original Units: mg/m3)
PAC-1 PAC-2 PAC-3
7.0 77 460
Converted PAC Values (ppm)
PAC-1 PAC-2 PAC-3
1.00 11 66
Technical Basis
A review of available sources identified acute toxicity data (LDLo, LD50) for various species and routes. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. Three rat oral LD50 doses were evaluated for the TEEL-3 basis; the most recent dose that was not reported as a mixture, was selected as the TEEL-3 basis. TEEL-1 and TEEL-2 values were derived according to Table 3.5.
• PAC-1 = TEEL-1 = TEEL-2/11
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Rat oral LD50 (2330 mg/kg)
This review generated PAC values consistent with Rev. 29A*.
References
Chemical information: https://pubchem.ncbi.nlm.nih.gov/compound/P-Toluenesulfonamide.
Rat oral LD50 (2330 mg/kg). European Agency for the Evaluation of Medicinal Products; Committee for Veterinary Medicinal Products; Tosylchloramide Sodium Summary Report (February 1999) EMEA/MRL/570/99-FINAL. Available from, as of November 8, 2017: https://www.ema.europa.eu/docs/en_GB/document_library/Maximum_Residue_Limits_-_Report/2009/11/WC500015637.pdf. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/P-Toluenesulfonamide.
Rat oral LD50 (2400 mg/kg) (Mixture of ortho-toluenesulfonamide (41%) and para-toluenesulfonamide (51%). European Agency for the Evaluation of Medicinal Products; Committee for Veterinary Medicinal Products; Tosylchloramide Sodium Summary Report (February 1999) EMEA/MRL/570/99-FINAL. Available from, as of November 8, 2017: https://www.ema.europa.eu/docs/en_GB/document_library/Maximum_Residue_Limits_-_Report/2009/11/WC500015637.pdf. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/P-Toluenesulfonamide
Rat oral LD50 (>2000 mg/kg). OECD; Screening Information Data Set (SIDS) for High Production Volume Chemicals, p.12 (September 1995). Available from, as of November 8, 2017: https://www.inchem.org/pages/sids.html. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/P-Toluenesulfonamide
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PAC values marked with a subscript "A" correspond to 60-minute AEGL values.
PAC values marked with a subscript "E" correspond to ERPG values.
PAC values marked by * are >= 10% lower explosive limit (LEL) but < 50% LEL.
PAC values marked by ** are > 50% LEL but < 100% LEL.
PAC values marked by *** are >= LEL.