PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Tri(2-ethylhexyl) phosphate; (Trioctyl phosphate) | 78-42-2 | 8027 |
15.01
15.02
7.11
10.00
3.09
3.02
3.10
3.07
3.01
3.11
|
|||||||||
| Formula | Synonyms | |||||||||||
| C24H51O4P | TRIS(2-ETHYLHEXYL)PHOSPHATE, 1-HEXANOL, 2-ETHYL, PHOSPHATE, 2-ETHYL-1-HEXANOL PHOSPHATE, DISFLAMOLL TOF, FLEXOL TOF, KRONITEX TOF, NCI-C54751, PHOSPHORIC ACID, TRIS(2-ETHYLHEXYL) ESTER, TEHP, TOF, TOP, TRI(2-ETHYLHEXYL) PHOSPHATE, TRI(2-ETHYLHEXYL)PHOSPHATE, TRIETHYLHEXYL PHOSPHATE, TRIOCTYL PHOSPHATE, TRIS(2-ETHYLHEXYL) PHOSPHATE | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 434.72 | L | -74 | 226.9 | 0.03 | 20 | 0.9077 |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 110 | 1200 | 7300 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 6.2 | 67 | 410 |
Technical Basis
A review of available sources identified acute toxicity data (LD50, LC50) for several species and routes. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. A guinea pig LC50 was considered as a TEEL-3 basis but was not selected because it was several orders of magnitude less than all other toxicity data. Considering this, analysts instead selected a rat oral LD50 as the TEEL-3 basis. TEEL-2 and TEEL-1 values were derived according to Table 3.5.
• PAC-1 = TEEL-1 = TEEL-2/11
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Rat oral LD50 (37 g/kg)
This review generated PAC values inconsistent with Rev. 29A. The Rev. 29A TEEL-3 basis was mouse oral LD50, while the current TEEL-3 basis is a more preferred species, a rat oral LD50 (rat > mouse, Section 3.3.4). The Rev. 29A and current TEEL-2/TEEL-1 use the same methodology, with differences due to the change in TEEL-3.
• PAC-1 = TEEL-1 = TEEL-2/11
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Rat oral LD50 (37 g/kg)
This review generated PAC values inconsistent with Rev. 29A. The Rev. 29A TEEL-3 basis was mouse oral LD50, while the current TEEL-3 basis is a more preferred species, a rat oral LD50 (rat > mouse, Section 3.3.4). The Rev. 29A and current TEEL-2/TEEL-1 use the same methodology, with differences due to the change in TEEL-3.
References
Chemical information: https://pubchem.ncbi.nlm.nih.gov/compound/Trioctyl-phosphate
Rat LD50: Prehled Prumyslove Toxikologie; Organicke Latky, Marhold, J., Prague, Czechoslovakia, Avicenum, 1986, -(1133), 1986. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/6537#section=Acute-Effects
Guinea pig LC50 (450 mg/m3/30M; TEEL-3=6.3 mg/m3) Prehled Prumyslove Toxikologie; Organicke Latky, Marhold, J., Prague, Czechoslovakia, Avicenum, 1986, (1133), 1986 Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/Trioctyl-phosphate