PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Trichloroacetyl chloride | 76-02-8 | 2442 |
14.01
11.01
14.02
7.01
4.07
|
|||||||||
| Formula | Synonyms | |||||||||||
| C2-Cl4-O | TRICHLOROACETYL CHLORIDE, ACETYL CHLORIDE, TRICHLORO-, CHLORURE DE TRICHLORACÉTYLE (DOT FRENCH), CLORURO DE TRICLOROACETILO (DOT SPANISH), TRICHLOROACETIC ACID CHLORIDE, TRICHLOROACETOCHLORIDE | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 181.82 | L | -146 | 21.32 | 25 | 1.629 |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.41 | 4.5 | 21 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.055 | 0.61 | 2.8 |
Technical Basis
A review of available sources identified the following: rat and mouse LC50 and rat oral LD50 toxicity data. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. Inhalation exposures were scaled to 60-minute equivalents using the ten Berge equation (Section 3.3.4). The rat LC50 was the most preferred route and species and was selected as the TEEL-3 basis. The LOC was selected as the TEEL-2, and the TEEL-1 value was calculated according to Table 3.5.
• TEEL-1 = TEEL-2/11
• TEEL-2 = LOC (0.0045 g/m3)
• TEEL-3 = Rat LC50 (475 mg/m3/4H)
This review generated TEEL-2 and TEEL-1 values that are inconsistent with Rev. 29A. While there are no changes to the TEEL methods it is unclear why the LOC located in this review differs from the one found and used in Rev. 29A, which resulted in differing TEEL-2 and TEEL-1 values for this review.
• TEEL-1 = TEEL-2/11
• TEEL-2 = LOC (0.0045 g/m3)
• TEEL-3 = Rat LC50 (475 mg/m3/4H)
This review generated TEEL-2 and TEEL-1 values that are inconsistent with Rev. 29A. While there are no changes to the TEEL methods it is unclear why the LOC located in this review differs from the one found and used in Rev. 29A, which resulted in differing TEEL-2 and TEEL-1 values for this review.
References
Rat LC50: Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure, Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982, -(113), 1982 via PubChem; National Center for Biotechnology Information (2023). PubChem Compound Summary for CID 6420, Trichloroacetyl chloride. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Trichloroacetyl-chloride.
LOC: Appendix C, pg. C-9: https://www.epa.gov/sites/default/files/2015-09/documents/technical_guidance_for_hazard_analysis.pdf