PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Trifluoroacetic acid; (Trifluoroethanoic acid) | 76-05-1 | 2699 |
14.01
11.01
14.02
4.08
7.01
8.00
11.00
4.07
3.09
3.02
|
|||||||||
| Formula | Synonyms | |||||||||||
| C2HF3O2 | TRIFLUOROACETIC ACID, 2,2,2-TRIFLUOROACETIC ACID, ACIDE TRIFLUORACÉTIQUE (DOT FRENCH), ACIDO TRIFLUOROACÉTICO (DOT SPANISH), PERFLUOROACETIC ACID, TRIFLUOROETHANOIC ACID | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 114.03 | L | -15.25 | 71.1 | 1.535 |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 6.7 | 73 | 440 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 1.4 | 16 | 94 |
Technical Basis
A review of available sources identified rat and mouse oral and intraperitoneal LDLo and LC50 inhalation data, as well as mouse intravenous LD50 toxicity data. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. Inhalation exposures were scaled to 60-minute equivalents using the ten Berge equation (Section 3.3.4). The most preferred exposure of rat LC50 data was the starting point to estimate a TEEL-3. TEEL-2 and TEEL-1 values were calculated according to Table 3.5.
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = Rat LC50 (10000 mg/m3/4H)
This review generated TEEL values that are inconsistent with those found in Rev 29A. In this review, the TEEL-3 data source, a rat LC50, was more preferable than the rat oral LD50 used in Rev. 29A.
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = Rat LC50 (10000 mg/m3/4H)
This review generated TEEL values that are inconsistent with those found in Rev 29A. In this review, the TEEL-3 data source, a rat LC50, was more preferable than the rat oral LD50 used in Rev. 29A.
References
National Center for Biotechnology Information (2023). PubChem Compound Summary for CID 6422, Trifluoroacetic Acid. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Trifluoroacetic-Acid.
https://haz-map.com/Agents/1436
Rat LC50: Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases., 10(3)(13), 1966 via PubChem; National Center for Biotechnology Information (2023). PubChem Compound Summary for CID 6422, Trifluoroacetic Acid. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Trifluoroacetic-Acid.