Technical Basis
A review of available sources identified mouse and rat oral acute toxicity data (LDLo). Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. The most preferred species and route, a rat oral LDLo, was selected as the TEEL-3 basis. TEEL-2 and TEEL-1 values were derived according to Table 3.5.
• PAC-1 = TEEL-1 = TEEL-2/11
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Rat oral LDLo (100 mg/kg)
This review generated PAC values consistent with Rev. 29A*.
References
Chemical information: https://pubchem.ncbi.nlm.nih.gov/compound/Divinyl-sulfoxide
Rat LDLo. National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review., 5(43), 1953 Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/Divinyl-sulfoxide