PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Bis(2-chloroethoxy)ethane, 1,2-; (Triglycol dichloride) | 112-26-5 |
14.01
16.02
11.01
4.03
4.10
7.01
4.09
4.07
|
||||||||||
| Formula | Synonyms | |||||||||||
| C6.H12.Cl2.O2 | ||||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 187.08 | L | -31.5 | 241.3 | 0.06 | 20 | 1.197 |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.49 | 5.4 | 32 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.064 | 0.71 | 4.2 |
Technical Basis
A review of available sources identified LD50 acute toxicity data for various species (rat, rabbit, guinea pig) and routes (oral, skin). Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. Two oral LD50 toxicity data for rat and guinea pig were evaluated for the TEEL-3 basis. Although rat is a more preferred species, the data was from a Union Carbide data sheet and it was not considered as technically reliable as the journal publication. Instead, the guinea pig oral LD50 was selected as the TEEL-3 basis since it was from a reputable source. TEEL-1 and TEEL-2 values were derived according to Table 3.5.
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = Guinea pig oral LD50 (120 mg/kg)
This review generated TEEL values that are inconsistent with Rev. 29A. The Rev. 29A TEEL-3 basis was the rat oral LD50 found in this review; however, due to reputability, the guinea pig oral LD50 was selected. The TEEL-2 and TEEL-1 methodology remains consistent, with the difference in values due to the change in the TEEL-3 basis.
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = Guinea pig oral LD50 (120 mg/kg)
This review generated TEEL values that are inconsistent with Rev. 29A. The Rev. 29A TEEL-3 basis was the rat oral LD50 found in this review; however, due to reputability, the guinea pig oral LD50 was selected. The TEEL-2 and TEEL-1 methodology remains consistent, with the difference in values due to the change in the TEEL-3 basis.
References
Chemical information: https://pubchem.ncbi.nlm.nih.gov/compound/1_2-Bis_2-chloroethoxy_ethane. and https://www.tcichemicals.com/US/en/p/B0471
Rat oral LD50. Union Carbide Data Sheet 8/28/1957. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/1_2-Bis_2-chloroethoxy_ethane.
Guinea pig oral LD50. Journal of Industrial Hygiene and Toxicology., 23(259), 1941. Retrieved from: https://puchem.ncbi.nlm.nih.gov/compound/1_2-Bis_2-chloroethoxy_ethane.