PAC Database - Detailed Chemical Data

Chemical Identity
Chemical CAS# UN# Health Code Numbers
Staphylococcal enterotoxin (SEB); including 37337-57-8 (SEA) 11100-45-1
4.06
4.07
11.00
11.01
Formula Synonyms
Unspecified
Physical Properties
Mol Wt State MP (°C) BP (°C) VP (Hg) VP (°C) SG LEL (ppm)
0 S
PAC Values
PAC Values (Original Units: mg/m3)
PAC-1 PAC-2 PAC-3
0.00019 0.0021 0.013
Converted PAC Values (ppm)
PAC-1 PAC-2 PAC-3
0 0 0
Technical Basis
A review of available sources identified mouse and monkey acute toxicity data (LD50, LDLo). Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.6.2, 3.6.3, 3.6.4, and evaluated using factors in Tables 3.2, 3.3, and 3.4. The most preferred species acute toxicity data, a monkey LDLo, was selected as the TEEL-3 basis. TEEL-2 and TEEL-1 values were derived according to Table 3.5.
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = Monkey intraperitoneal LDLo (25 µg/kg)
This review generated TEEL values that are consistent with Rev. 29A
References
Description and approximate molecular weight retrieved from: https://wwwnc.cdc.gov/eid/article/10/9/04-0250_article
Monkey intraperitoneal LDLo (25 µg/kg). Refer to materials and method section, pg. 446 (dose) and 447 (mortality rate). Crawley GJ, Black JN, Gray I, Blanchard JW. Appl Microbiol. 1966 May;14(3):445-50. doi: 10.1128/am.14.3.445-450.1966. PMID: 4961554; PMCID: PMC546739
Mouse intraperitoneal LD50 (0.2 ug/kg), retrieved from: LeClaire RD, Hunt RE, Bavari S. Infect Immun. 2002 May;70(5):2278-81. doi: 10.1128/IAI.70.5.2278-2281.2002. PMID: 11953360; PMCID: PMC127924.
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PAC values marked with a subscript "A" correspond to 60-minute AEGL values.
PAC values marked with a subscript "E" correspond to ERPG values.
PAC values marked by * are >= 10% lower explosive limit (LEL) but < 50% LEL.
PAC values marked by ** are > 50% LEL but < 100% LEL.
PAC values marked by *** are >= LEL.