PAC Database - Detailed Chemical Data

Chemical Identity
Chemical CAS# UN# Health Code Numbers
Tetanus toxin 676570-37-9
7.00
7.01
Formula Synonyms

Physical Properties
Mol Wt State MP (°C) BP (°C) VP (Hg) VP (°C) SG LEL (ppm)
0 S
PAC Values
PAC Values (Original Units: mg/m3)
PAC-1 PAC-2 PAC-3
0.000000015 0.00000017 0.0000010
Converted PAC Values (ppm)
PAC-1 PAC-2 PAC-3
0 0 0
Technical Basis
A review of available sources identified acute toxicity data for several species and routes. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.6.2, 3.6.3, 3.6.4 and evaluated using factors in Tables 3.2, 3.3, and 3.4. The most preferred species, a monkey intravenous LDLo, was selected as the TEEL-3 basis. TEEL-2 and TEEL-1 values were derived according to Table 3.5.
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = Monkey intravenous LDLO (2 ng/kg)
This review generated TEEL values that are inconsistent with Rev. 29A. The Rev. 29A basis was a mouse intraperitoneal LD50 data while the current basis is a more preferred species (monkey > mouse) from a recent source (2019) that studied the effects of the whole isolated toxin.
References
Dog intravenous LDLo (240 ng/kg ), Table 4. Rossetto, O., Montecucco, C., 2019. Toxins 11, 686. https://doi.org/10.3390/toxins11120686
Monkey intravenous LDLo (2 ng/kg), Table 4. Rossetto, O., Montecucco, C., 2019. Toxins 11, 686. https://doi.org/10.3390/toxins11120686
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PAC values marked with a subscript "A" correspond to 60-minute AEGL values.
PAC values marked with a subscript "E" correspond to ERPG values.
PAC values marked by * are >= 10% lower explosive limit (LEL) but < 50% LEL.
PAC values marked by ** are > 50% LEL but < 100% LEL.
PAC values marked by *** are >= LEL.