PAC Database - Detailed Chemical Data

Chemical Identity
Chemical CAS# UN# Health Code Numbers
Conotoxins α 156467-85-5
4.06
4.10
7.01
11.00
Formula Synonyms
C52H82N20O15S4
Physical Properties
Mol Wt State MP (°C) BP (°C) VP (Hg) VP (°C) SG LEL (ppm)
1355.6 S
PAC Values
PAC Values (Original Units: mg/m3)
PAC-1 PAC-2 PAC-3
0.000039 0.00043 0.0026
Converted PAC Values (ppm)
PAC-1 PAC-2 PAC-3
0.00000070 0.0000078 0.000047
Technical Basis
A review of available sources identified mouse acute toxicity data. Toxicity data was selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.6.2, 3.6.3, 3.6.4, and evaluated using factors in Tables 3.2, 3.3, and 3.4. TEEL-2 and TEEL-1 values were derived according to Table 3.5.
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = Mouse intraperitoneal LD50 (12 µg/kg)
This review generated TEEL values inconsistent with Rev. 29A. The Rev. 29A TEEL-3 basis was also a mouse intraperitoneal LD50 but was not an equivalent dose to the currently identified source. The Rev. 29A and current TEEL-2 and TEEL-1 values were derived using the same methodology, with differences due to the change in TEEL-3 toxicity dose.
References
CASRN PubChem record: https://pubchem.ncbi.nlm.nih.gov/substance/481155197
alpha-Conotoxin imi record (molecular weight, molecular formula): https://pubchem.ncbi.nlm.nih.gov/compound/133011
General description: https://pubmed.ncbi.nlm.nih.gov/11091135/
Cruz, L.J.; Gray, W.R.; Olivera, B.M. Purification and properties of a myotoxin from Conus geographus venom. Arch. Biochem. Biophys. 1978, 190, 539–548. https://doi.org/10.1016/0003-9861(78)90308-9
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PAC values marked with a subscript "A" correspond to 60-minute AEGL values.
PAC values marked with a subscript "E" correspond to ERPG values.
PAC values marked by * are >= 10% lower explosive limit (LEL) but < 50% LEL.
PAC values marked by ** are > 50% LEL but < 100% LEL.
PAC values marked by *** are >= LEL.