PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Shigella, shigatoxin; (shiga-like toxins) | 75757-64-1 |
4.06
4.07
4.09
|
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| Formula | Synonyms | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 0 | S |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 8.9E-08 | 9.7E-07 | 5.8E-06 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0 | 0 | 0 |
Technical Basis
A review of available sources identified the mouse LD50 for intraperitoneal and intravenous routes. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.6.3, 3.6.4, and evaluated using factors in Tables 3.2, 3.3, and 3.4. Of the available sources, the most current (1993) and lowest report intraperitoneal LD50 dose was selected (27 ng/kg). TEEL-2 and TEEL-1 values were derived according to Table 3.5.
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = Mouse intraperitoneal LD50 (27 ng/kg)
This review generated TEEL values which are more conservative than Rev. 29A. The Rev. 29A TEEL-3 basis was identified during the current review (see reference 3), however the current basis is from a more preferred route (Section 3.6.4) and a more recent source (1993 vs. 1983). Differences in TEEL-2 and TEEL-1 are due to the change in TEEL-3.
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = Mouse intraperitoneal LD50 (27 ng/kg)
This review generated TEEL values which are more conservative than Rev. 29A. The Rev. 29A TEEL-3 basis was identified during the current review (see reference 3), however the current basis is from a more preferred route (Section 3.6.4) and a more recent source (1993 vs. 1983). Differences in TEEL-2 and TEEL-1 are due to the change in TEEL-3.
References
Mouse intravenous LD50 (450 ng/kg). Journal of Immunology., 130(380), 1983 [PMID:6336624]. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/substance/135281105
Mouse intraperitoneal LD50 (250 ng/kg). Journal of Immunology., 130(380), 1983 [PMID:6336624]. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/substance/135281105.
Mouse intraperitoneal LD50 (28 ng/kg). Yutsudo, Takashi; Honda, Takeshi; Miwatani, Toshio; Takeda, Yoshifumi. ISSN: 0385-5600 , 1348-0421. Retrieved from: https://doi.org/10.1111/j.1348-0421.1986.tb03041.x
Mouse intraperitoneal LD50 (27 ng/kg). Takeda, Y., Kurazono, H. and Yamasaki, S. (1993), Microbiology and Immunology, 37: 591-599. https://doi.org/10.1111/j.1348-0421.1993.tb01681.x