PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Modeccin toxin; (Adenia digitata toxin) | 65988-88-7 |
4.07
4.10
|
||||||||||
| Formula | Synonyms | |||||||||||
| [Unspecified] | ||||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 0 | S |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.0000078 | 0.000086 | 0.00051 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0 | 0 | 0 |
Technical Basis
A review of available sources identified a mouse and rat acute toxicity data (LD50). Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.6.2, 3.6.3, 3.6.4, and evaluated using factors in Tables 3.2, 3.3, and 3.4. The most preferred species toxicity data, a rat intraperitoneal LD50, was selected as the TEEL-3 basis. TEEL-2 and TEEL-1 values were derived according to Table 3.5.
• TEEL-1 = TEEL-2/11
• TEEL-2 =TEEL-3/6
• TEEL-3 = Rat intraperitoneal LD50 (1300 ng/kg)
This review generated TEEL values inconsistent with Rev. 29A. The Rev. 29A and current TEEL-3 bases are the same, rat intraperitoneal LD50; however, Rev. 29A source was not found during the review and the current dose is less conservative. The Rev. 29A and current TEEL-2 and TEEL-1 use the same methodology, with differences due to the change in TEEL-3.
• TEEL-1 = TEEL-2/11
• TEEL-2 =TEEL-3/6
• TEEL-3 = Rat intraperitoneal LD50 (1300 ng/kg)
This review generated TEEL values inconsistent with Rev. 29A. The Rev. 29A and current TEEL-3 bases are the same, rat intraperitoneal LD50; however, Rev. 29A source was not found during the review and the current dose is less conservative. The Rev. 29A and current TEEL-2 and TEEL-1 use the same methodology, with differences due to the change in TEEL-3.
References
Description and molecular weight retrieved from: Biochem J. 1978 Aug 15;174(2):491-6. doi: 10.1042/bj1740491. See pg. 493, Table 1 for Rat LD50. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1185939/
Rat LD50. Biochemical Journal., 174(491), 1978 [PMID:708401]. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/substance/135288417