PAC Database - Detailed Chemical Data

Chemical Identity
Chemical CAS# UN# Health Code Numbers
Viscumin; (Mistletoe lectin) 83590-17-4
4.08
4.10
Formula Synonyms
[Unspecified]
Physical Properties
Mol Wt State MP (°C) BP (°C) VP (Hg) VP (°C) SG LEL (ppm)
0 S
PAC Values
PAC Values (Original Units: mg/m3)
PAC-1 PAC-2 PAC-3
0.00077 0.0085 0.051
Converted PAC Values (ppm)
PAC-1 PAC-2 PAC-3
0 0 0
Technical Basis
A review of limited available sources identified mouse intravenous LD50 toxicity data, which was selected as the TEEL-3 basis (Section 3.6.4). This LD50 was evaluated using factors in Tables 3.2, 3.3, and 3.4. TEEL-2 and TEEL-1 values were calculated according to Table 3.5.
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = Mouse intravenous LD50 (235 µg/kg)
This review generated TEEL values inconsistent with those published in Rev. 29A; although the same source is cited, the results are two orders of magnitude different. This may be attributed to 1) a conversion error of the dose, or 2) incorrectly reading the table where the source was referenced from. The current recommendation is less conservative that Rev. 29A, while remaining very restrictive.
References
https://www.sciencedirect.com/topics/medicine-and-dentistry/viscum-album
https://www.guidechem.com/dictionary/en/83590-17-4.html
Table 1, page 2; Olsnes, S., Stirpe, F., Sandvig, K., & Pihl, A. (1982). Isolation and characterization of viscumin, a toxic lectin from Viscum album L. (mistletoe). Journal of Biological Chemistry, 257, 13263–13270: https://www.jbc.org/article/S0021-9258(18)33440-9/pdf
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PAC values marked with a subscript "A" correspond to 60-minute AEGL values.
PAC values marked with a subscript "E" correspond to ERPG values.
PAC values marked by * are >= 10% lower explosive limit (LEL) but < 50% LEL.
PAC values marked by ** are > 50% LEL but < 100% LEL.
PAC values marked by *** are >= LEL.